Evidence map›Paper›PMID 34409924›Full record

ArticleAmerican journal of respiratory and critical care medicine2021

Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia.

Chiagozie O Pickens, Catherine A Gao, Michael J Cuttica, Sean B Smith, Lorenzo L Pesce, Rogan A Grant, Mengjia Kang, Luisa Morales-Nebreda, Avni A Bavishi, Jason M Arnold and 6 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 1 pooled it
23.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 1 synthesis or guideline pooled it, 184 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Observational
  5. Review
  6. Article
  7. Article
  8. Structured clinical adjudication ofFrontiers in medicine · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Antibiotic de-escalation patterns and outcomes in critically ill patients with suspected pneumonia as informed by bronchoalveolar lavage results.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Chiagozie O PickensDivision of Pulmonary and Critical Care, Department of Medicine.
Catherine A GaoDivision of Pulmonary and Critical Care, Department of Medicine.
Michael J CutticaDivision of Pulmonary and Critical Care, Department of Medicine.
Sean B SmithDivision of Pulmonary and Critical Care, Department of Medicine.
Lorenzo L PesceDepartment of Pharmacology.
Rogan A GrantDivision of Pulmonary and Critical Care, Department of Medicine.
Mengjia KangDivision of Pulmonary and Critical Care, Department of Medicine.
Luisa Morales-NebredaDivision of Pulmonary and Critical Care, Department of Medicine.
Avni A BavishiDivision of Pulmonary and Critical Care, Department of Medicine.ORCID 0000-0003-4140-0599
Jason M ArnoldDivision of Pulmonary and Critical Care, Department of Medicine.ORCID 0000-0001-8687-0063
Anna PawlowskiClinical Translational Sciences Institute, and.
Chao QiDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
G R Scott BudingerDivision of Pulmonary and Critical Care, Department of Medicine.
Benjamin D SingerDivision of Pulmonary and Critical Care, Department of Medicine.ORCID 0000-0001-5775-8427
Richard G WunderinkDivision of Pulmonary and Critical Care, Department of Medicine.ORCID 0000-0002-8527-4195
NU COVID Investigators
Pulmonary and Critical Care Associates · USNorthwestern University · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE · 2015 to 2026
$26.9M
Technology CoreU19AI135964 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2018 to 2026
$24.7M
The Cell Phenotyping and Mouse CoreP01HL154998 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE · 2021 to 2026
$18.9M
PREDOCTORAL AND POSTDOCTORAL TRAINING PROGRAM IN AGING AND DEMENTIAT32AG020506 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR, SANDRA WEINTRAUB · 2002 to 2026
$9.9M
Training Program In Lung SciencesT32HL076139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE, Jacob I Sznajder · 2004 to 2026
$9.6M
Role of spleen educated monocytes in mediating ischemia-reperfusion injury followinglung transplant surgeryR01HL147575 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ankit Bharat, GR Scott Budinger · 2019 to 2026
$5.5M
Mechanisms of regulatory T cell-mediated recovery from severe viral pneumoniaR01HL149883 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2020 to 2026
$4.1M
Modeling the Incompleteness and Biases of Health DataR01LM013337 · NLM · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUO, YUAN · 2020 to 2023
$1.3M
Hypercapnia and Suppression of Anti-viral Host DefenseR01HL131745 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SPORN, PETER H · 2017 to 2019
$1.2M
Regulatory T cell Uhrf1 and DNA methylation in repair of acute lung injuryK08HL128867 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SINGER, BENJAMIN DAVID · 2015 to 2019
$779k
Dysfunction of microglial proteostasis drives neuroinflammation and cognitive decline following pneumoniaF31AG071225 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GRANT, ROGAN AARON · 2021 to 2023
$127k
NCATS NIH HHS UL1 TR001422NHLBI NIH HHS K08 HL128867NHLBI NIH HHS P01 HL154998NHLBI NIH HHS R01 HL131745NHLBI NIH HHS R01 HL147575NHLBI NIH HHS R01 HL149883NHLBI NIH HHS R01 HL153122NHLBI NIH HHS T32 HL076139NIAID NIH HHS U19 AI135964NIA NIH HHS F31 AG071225NIA NIH HHS P01 AG049665NIA NIH HHS T32 AG020506NLM NIH HHS R01 LM013337
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

bronchoalveolar lavagecommunity-acquired pneumoniaCOVID-19guideline therapyventilator-associated pneumonia

Identifiers

PMID34409924
PMCPMC8534629
OpenAlexW3195991616

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.