ArticleBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2021
Characterization of the association between cigarette smoking intensity and urinary concentrations of 2-hydroxyethyl mercapturic acid among exclusive cigarette smokers in the National Health and Nutrition Examination Survey (NHANES) 2011-2016.
Article in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- Positive association of ethylene oxide levels with young stroke: a population-based study.Frontiers in aging neuroscience · 2024Article
- Cigarette smoking is associated with acrylamide exposure among the U.S. population: NHANES 2011-2016.Environmental research · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
background2-Hydroxyethyl mercapturic acid (2HEMA, N-acetyl-S-(2-hydroxyethyl)-L-cysteine) is a urinary metabolite of several volatile organic compounds including acrylonitrile and ethylene oxide, which are found in cigarette smoke.
methodsWe measured 2HEMA concentrations in urine specimens collected during the National Health and Nutrition Examination Survey (2011-2016) from eligible participants aged >12 years (
resultsWe detected 2HEMA in 85% of samples tested among exclusive cigarette smokers, and only 40% of specimens from non-smokers. When compared to exclusive cigarette smokers who smoked 1-9 CPD, smoking 10-19 CPD was associated with 36% higher 2HEMA (
conclusionsThis study demonstrates that cigarette smoking intensity is associated with higher urinary 2HEMA concentrations and is likely a major source of acrylonitrile and/or ethylene oxide exposure.
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