Evidence map›Paper›PMID 34409851›Full record

ArticleTissue engineering. Part A2022

Sarah Carney, Tom Broekelmann, Robert Mecham, Anand Ramamurthi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sarah CarneyDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio, USA.
Tom BroekelmannDepartment of Cell Biology and Physiology, Washington University at St. Louis, St. Louis, Missouri, USA.
Robert MechamDepartment of Cell Biology and Physiology, Washington University at St. Louis, St. Louis, Missouri, USA.
Anand RamamurthiDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, Ohio, USA.
Case Western Reserve University · USCleveland Clinic Lerner College of Medicine · US

Funding

ASSEMBLY OF LUNG ELASTINR01HL053325 · NHLBI · WASHINGTON UNIVERSITY · PI MECHAM, ROBERT P. · 1995 to 2019
$3.6M
Transmission Electron MicroscopeS10RR031536 · NCRR · CLEVELAND CLINIC LERNER COM-CWRU · PI DRAZBA, JUDY · 2011 to 2011
$518k
NCRR NIH HHS S10 RR031536NHLBI NIH HHS R01 HL053325
6 · The paper itself

Abstract

Elastic fibers do not naturally regenerate in many proteolytic disorders, such as in abdominal aortic aneurysms, and prevent restoration of tissue homeostasis. We have shown drug-based attenuation of the stress-activated protein kinase, JNK-2 to stimulate elastic matrix neoassembly and to attenuate cellular proteolytic activity. We now investigate if

Indexed as

Extracellular MatrixMyocytes, Smooth MuscleAnimalsGene SilencingPolyethyleneimineRatsRats, Sprague-DawleyRegenerationRNA, Small InterferingPolyethyleneimineRNA, Small Interferingelastinextracellular matrixvascular tissue repair

Identifiers

PMID34409851
PMCPMC8972024
OpenAlexW3193908205

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.