Evidence map›Paper›PMID 34409766›Full record

ArticleJournal of applied clinical medical physics2021

Optical emission-based phantom to verify coincidence of radiotherapy and imaging isocenters on an MR-linac.

Jacqueline M Andreozzi, Petr Brůža, Jochen Cammin, Daniel A Alexander, Brian W Pogue, Olga Green, David J Gladstone

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jacqueline M AndreozziThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Petr BrůžaThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Jochen CamminDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.
Daniel A AlexanderThayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Brian W PogueThayer School of Engineering and Department of Physics and Astronomy, Dartmouth College, Hanover, New Hampshire, USA.
Olga GreenDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.
David J GladstoneNorris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
DoseRT™ : A Non-Contact Optical Patient and Beam Dosimetry System for Continuous in vivo Radiotherapy VerificationR44CA232879 · NCI · DOSEOPTICS, LLC · PI William Ware · 2018 to 2026
$5.2M
OPTICAL CHERENKOV IMAGING DOSIMETRY IN HUMAN RADIOTHERAPYR01EB023909 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI GLADSTONE, DAVID J., JARVIS, LESLEY A · 2017 to 2024
$4.4M
Real-time Cherenkov imaging system for whole-breast radiotherapy verificationF31CA192473 · NCI · DARTMOUTH COLLEGE · PI ANDREOZZI, JACQUELINE · 2016 to 2017
$88k
NCI NIH HHS F31 CA192473NCI NIH HHS P30 CA023108NCI NIH HHS R44 CA232879NIBIB NIH HHS R01 EB023909
6 · The paper itself

Abstract

purposeDemonstrate a novel phantom design using a remote camera imaging method capable of concurrently measuring the position of the x-ray isocenter and the magnetic resonance imaging (MRI) isocenter on an MR-linac.

methodsA conical frustum with distinct geometric features was machined out of plastic. The phantom was submerged in a small water tank, and aligned using room lasers on a MRIdian MR-linac (ViewRay Inc., Cleveland, OH). The phantom physical isocenter was visualized in the MR images and related to the DICOM coordinate isocenter. To view the x-ray isocenter, an intensified CMOS camera system (DoseOptics LLC., Hanover, NH) was placed at the foot of the treatment couch, and centered such that the optical axis of the camera was coincident with the central axis of the treatment bore. Two or four 8.3mm x 24.1cm beams irradiated the phantom from cardinal directions, producing an optical ring on the conical surface of the phantom. The diameter of the ring, measured at the peak intensity, was compared to the known diameter at the position of irradiation to determine the Z-direction offset of the beam. A star-shot method was employed on the front face of the frustum to determine X-Y alignment of the MV beam. Known shifts were applied to the phantom to establish the sensitivity of the method.

resultsCouch translations, demonstrative of possible isocenter misalignments, on the order of 1mm were detectable for both the radiotherapy and MRI isocenters. Data acquired on the MR-linac demonstrated an average error of 0.28mm(N=10, R

conclusionsThe phantom was capable of measuring both the MRI and radiotherapy treatment isocenters. This method has the potential to be of use in MR-linac commissioning, and could be streamlined to be valuable in daily constancy checks of isocenter coincidence.

Indexed as

Particle AcceleratorsRadiotherapy, Image-GuidedHumansMagnetic Resonance ImagingPhantoms, ImagingRadiotherapy Planning, Computer-AssistedCerenkovCherenkovisocenter coincidenceMRIgRTQAscintillationstar shot

Identifiers

PMID34409766
PMCPMC8425893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.