ArticleJournal of thrombosis and haemostasis : JTH2021
No prospective association of a polygenic risk score for coronary artery disease with venous thromboembolism incidence.
Article in Journal of thrombosis and haemostasis : JTH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Endovascular management of symptomatic May-Thurner syndrome: real-world procedural approaches and outcomes.Proceedings (Baylor University. Medical Center) · 2026Article
- Risk factors for thrombotic events in systemic lupus erythematosus patients with antiphospholipid antibodies: insights from morphometric measurements of carotid arteries.Frontiers in cardiovascular medicine · 2024Article
- Epidemiology and prevention of venous thromboembolism.Nature reviews. Cardiology · 2023Review
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Authors and funding
3 authors at 3 institutions in 1 country.
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Abstract
backgroundPrevious studies are inconsistent about whether chronic coronary artery disease or generalized atherosclerosis is a causal risk factor for venous thromboembolism. No study seems to have taken a genomic approach to this question.
objectiveTo test in a prospective study whether a polygenic risk score for coronary artery disease is associated with risk of venous thromboembolism. PARTICIPANTS/
methodsWithin the Atherosclerosis Risk in Communities Study cohort, we computed a previously validated polygenic risk score for coronary artery disease among 9144 White participants at baseline in 1987-1989. We followed the participants through 2015 for incident hospitalized venous thromboembolism events, validated by physician review. We used Cox proportional hazards regression to associate quintiles of the polygenic risk score to venous thromboembolism incidence rates.
resultsOver the median of 26 years of follow-up, 476 participants had a venous thromboembolism event. There was no apparent association between the coronary artery disease polygenic risk score and incident venous thromboembolism, with age, sex, body mass index adjusted hazard ratios across quintiles being 1 (reference), 0.87 (0.65, 1.15), 1.08 (0.82, 1.42), 0.96 (0.72, 1.27), and 1.03 (0.78, 1.37).
conclusionsA genetic disposition to coronary artery disease did not confer an increased risk of venous thromboembolism in this prospective study.
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