ArticleSchizophrenia bulletin2022
Psychosis Biotypes: Replication and Validation from the B-SNIP Consortium.
Article in Schizophrenia bulletin, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 4 of them syntheses that pooled it.
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Who cites it
70 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of the auditory steady-state response in schizophrenia, bipolar disorder, and autism spectrum disorder.Molecular psychiatry · 2026Pooled it
- Transdiagnostic Neurocognitive Endophenotypes for Schizophrenia, Bipolar I Disorder and a Broad Psychosis/Bipolar I Disorder Phenotype: A Mega-Analysis of Twin and Sibling Data.Schizophrenia bulletin · 2026Pooled it
- Relationships Between Immune-Inflammatory Features and Social Cognitive Impairments in Patients With Schizophrenia Spectrum Disorders: A Systematic Review.Brain and behavior · 2025Pooled it
- Prognostic models predicting transition to psychotic disorder using blood-based biomarkers: a systematic review and critical appraisal.Translational psychiatry · 2023Pooled it
- Neurophysiological subtyping of schizophrenia reveals a reproducible phenotype with temporoparietal circuit disruptions.General psychiatry · 2026Article
- What Static Connectivity Misses: Dynamic Alpha-Band Brain Network States in First-Episode Psychosis.Brain topography · 2026Article
- Computerized adaptive testing of neurocognitive deficits in psychosis.Psychological assessment · 2026Article
- Subtyping psychotic disorders using a data-driven approach reveals divergent cortical and cellular signatures.Molecular psychiatry · 2026Article
- Polygenic associations with phenotypic classes across the psychosis-affective spectrum.medRxiv : the preprint server for health sciences · 2026Article
- Volume and Tempo: Cortical Excitability and Trial-to-Trial Consistency of Auditory Responses Distinguish Psychosis Biotypes.Research square · 2026Article
- Stress and synaptic density in psychosis and clinical high risk: evidence from [Translational psychiatry · 2026Article
- Delineating white matter phenotypes of sensori-/psychomotor functioning in large-scale cohorts of healthy individuals and patients with mental disorders across the lifespan (whiteSPAN): rationale and methods of an interdisciplinary bicentric project.European archives of psychiatry and clinical neuroscience · 2026Article
- DifferentialScience advances · 2026Article
- Excessive gamma and beta oscillations in manic states across mood and psychotic disorders.Scientific reports · 2026Article
- Threading the Needle: Practical Considerations for Merging Theory-Driven Computational Psychiatry With Data-Driven Analytics to Enhance Precision Health at Scale.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Review
- Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes.Schizophrenia bulletin · 2026Article
- Application of the research domain criteria in early-phase clinical development of transdiagnostic neurotherapeutics: A multidisciplinary perspective.Neuroscience applied · 2026Review
- Associations of social and genetic background variables to neuro-cognitive biomarkers of psychosis.Biomarkers in neuropsychiatry · 2025Article
- Subtyping schizophrenia via machine learning by using structural neuroimaging.Translational psychiatry · 2025Review
- Latent class analysis of symptoms across schizophrenia, schizoaffective disorder, and bipolar I disorder.medRxiv : the preprint server for health sciences · 2025Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Current clinical phenomenological diagnosis in psychiatry neither captures biologically homologous disease entities nor allows for individualized treatment prescriptions based on neurobiology. In this report, we studied two large samples of cases with schizophrenia, schizoaffective, and bipolar I disorder with psychosis, presentations with clinical features of hallucinations, delusions, thought disorder, affective, or negative symptoms. A biomarker approach to subtyping psychosis cases (called psychosis Biotypes) captured neurobiological homology that was missed by conventional clinical diagnoses. Two samples (called "B-SNIP1" with 711 psychosis and 274 healthy persons, and the "replication sample" with 717 psychosis and 198 healthy persons) showed that 44 individual biomarkers, drawn from general cognition (BACS), motor inhibitory (stop signal), saccadic system (pro- and anti-saccades), and auditory EEG/ERP (paired-stimuli and oddball) tasks of psychosis-relevant brain functions were replicable (r's from .96-.99) and temporally stable (r's from .76-.95). Using numerical taxonomy (k-means clustering) with nine groups of integrated biomarker characteristics (called bio-factors) yielded three Biotypes that were virtually identical between the two samples and showed highly similar case assignments to subgroups based on cross-validations (88.5%-89%). Biotypes-1 and -2 shared poor cognition. Biotype-1 was further characterized by low neural response magnitudes, while Biotype-2 was further characterized by overactive neural responses and poor sensory motor inhibition. Biotype-3 was nearly normal on all bio-factors. Construct validation of Biotype EEG/ERP neurophysiology using measures of intrinsic neural activity and auditory steady state stimulation highlighted the robustness of these outcomes. Psychosis Biotypes may yield meaningful neurobiological targets for treatments and etiological investigations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.