Evidence map›Paper›PMID 34409424›Full record

ReviewFaculty reviews2021

Emerging principles of cancer biophysics.

Woong Young So, Kandice Tanner

Abstract readReview
In one paragraph

Review in Faculty reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Woong Young SoLaboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Kandice TannerLaboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Funding

The Role of Coherent Rotation in Adult Tissue RemodelingZIABC011433 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TANNER, KANDICE · 2012 to 2025
$7.2M
The role of the tumor biofilm in determining tissue tropismZIABC011559 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TANNER, KANDICE · 2014 to 2025
$6.4M
Mechano-chemical regulation of the microenvironmental niche in melanomaZIABC011524 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TANNER, KANDICE · 2013 to 2025
$6.2M
6 · The paper itself

Abstract

Cancer is a multi-step process where normal cells become transformed, grow, and may disseminate to establish new lesions within the body. In recent years, the physical properties of individual cells and the tissue microenvironment have been shown to be potent determinants of cancer progression. Biophysical tools have long been used to examine cell and tissue mechanics, morphology, and migration. However, exciting developments have linked these physical traits to gene expression changes that drive metastatic seeding, organ selectivity, and tumor growth. Here, we present some vignettes to address recent studies to show progress in harnessing biophysical tools and concepts to gain insights into metastasis.

Indexed as

microenvironmentrheologytissue biophysics

Identifiers

PMID34409424
PMCPMC8361748

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.