Evidence map›Paper›PMID 34409385›Full record

ArticleJAAD international2021

Atopic dermatitis is associated with hidradenitis suppurativa diagnosis: A single institution retrospective cohort study.

Rayan N Kaakati, John Tanaka, Beiyu Liu, Rachael Ward, Amanda S Macleod, Cynthia L Green, Tarannum Jaleel

Open access · goldAbstract read
In one paragraph

Article in JAAD international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Rayan N KaakatiDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
John TanakaDepartment of Internal Medicine, Duke University School of Medicine, Durham, North Carolina.
Beiyu LiuDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina.
Rachael WardDivision of Dermatology, University of Washington, Seattle, Washington.
Amanda S MacleodDepartment of Dermatology, Duke University Medical Center, Durham, North Carolina.
Cynthia L GreenDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, North Carolina.
Tarannum JaleelDepartment of Dermatology, Duke University Medical Center, Durham, North Carolina.
Duke Medical Center · USDuke University · USClinical Research Institute · USUniversity of Michigan–Ann Arbor · USUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHidradenitis suppurativa (HS) and atopic dermatitis (AD) are both chronic inflammatory skin diseases. An association between these 2 conditions can have important potential implications for elucidating pathogenesis, disease course, and treatment.

objectiveTo investigate the association between AD and HS.

methodsWe performed a retrospective cohort study of patients seen at Duke University Medical Center from 2007 to 2017 who had AD compared with a control group without an AD diagnosis. The association of AD and HS was evaluated using a logistic regression model after adjusting for other confounders including age, sex, and race.

resultsOf 28,780 patients with an AD diagnosis, 325 (1.1%) were diagnosed with HS compared with 76 (0.2%) within the 48,383 patients in the non-AD group. An adjusted logistic regression model demonstrated an increased odds ratio of having HS diagnosis in the AD group as compared with the control non-AD group (odds ratio: 5.57, 95% confidence interval: 4.30-7.21, LIMITATIONS: This was a retrospective study performed at a single institution with the possibility of surveillance bias being present.

conclusionsPatients with AD are more likely to be diagnosed with HS than patients without AD. Further research is needed to understand the pathophysiologic mechanism and potential treatment implications.

Indexed as

AD, atopic dermatitisAMP, antimicrobial peptideatopic dermatitisbarrier defectCI, confidence intervalclinical researchhidradenitis suppurativaHS, hidradenitis suppurativaICD, International Classification of Diseasesinflammatory skin diseasesnotch signalingOR, odds ratioPPV, positive predictive valueTSLP, thymic stromal lymphopoietin

Identifiers

PMID34409385
PMCPMC8362302
OpenAlexW3168498447

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.