ArticleJAAD international2020
Efficacy of intralesional sodium thiosulfate for the treatment of dystrophic calcinosis cutis: A double-blind, placebo-controlled pilot study.
Article in JAAD international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Local, non-systemic, and minimally invasive therapies for calcinosis cutis: a systematic review.Archives of dermatological research · 2022Pooled it
- Intralesional sodium thiosulfate-induced necrotic ulceration in calcinosis cutis.JAAD case reports · 2026Article
- Article
- Calcinosis Cutis Universalis: A Review of Therapeutic Strategies and Surgical Management.Journal of clinical medicine · 2026Review
- Calcinosis in dermatomyositis.Current opinion in rheumatology · 2024Review
- Treatment of Calcinosis in Dermatomyositis-Case Report and Review.Journal of clinical medicine · 2024Article
- Undiluted 25% intralesional sodium thiosulfate in the management of dystrophic calcinosis cutis.JAAD case reports · 2024Article
- Treatment of calcinosis cutis associated with autoimmune connective tissue diseases.Archives of dermatological research · 2024Review
- Distinguishing dystrophic calcification from calciphylaxis.JAAD case reports · 2023Article
- Calcinosis in dermatomyositis: Origins and possible therapeutic avenues.Best practice & research. Clinical rheumatology · 2022Review
- Recalcitrant digital calcinosis cutis successfully treated with intralesional sodium thiosulfate under digital nerve blockade.BMJ case reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntralesional injection of sodium thiosulfate has emerged as a promising therapy for calcinosis cutis, but to our knowledge there are no randomized controlled trials evaluating its efficacy as a treatment.
objectiveConduct a prospective, double-blinded investigation of intralesional sodium thiosulfate versus normal saline in the treatment of dystrophic calcinosis cutis.
methodsThis prospective pilot study injected normal saline or sodium thiosulfate at 0.1 mL/cm
resultsOf 4 subjects who completed the study, only 1 experienced improvement in the size and Physician Global Assessment score of the lesion. By 3-month follow-up, there was no difference between the average size of the treatment and control lesions ( LIMITATIONS: This was a small single-center study with limited demographic diversity and a short follow-up period. Only dystrophic calcinosis cutis subjects were included, and subjects received only 3 monthly injections of sodium thiosulfate.
conclusionsWith only 1 positive response, our results highlight the need for further study of sodium thiosulfate treatment for dystrophic calcinosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.