Evidence map›Paper›PMID 34409234›Full record

ArticleJournal of current ophthalmology

Sarcoid-Associated Bilateral Multifocal Choroiditis Secondary to Adalimumab.

Carl Stanley Wilkins, Kristen Taylor Ashourian, Ethan Kyle Sobol, Matthew Fink, Brian Saltzman, Steven Teich

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of current ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Carl Stanley WilkinsDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.
Kristen Taylor AshourianDepartment of Ophthalmology, Stroger Eye Clinic/Cook County Health, Chicago, IL, USA.
Ethan Kyle SobolDepartment of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA.
Matthew FinkDepartment of Neurology, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Brian SaltzmanIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Steven TeichIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Icahn School of Medicine at Mount Sinai · USNew York Eye and Ear Infirmary · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo report a rare paradoxical development of systemic sarcoidosis in a patient taking adalimumab manifesting as multifocal choroidal infiltrates and seventh nerve palsy.

methodsThis was a single patient case report.

resultsA 30-year-old man with a history of psoriatic arthritis on adalimumab presented with intermittent fevers and headaches. Initial infectious serology and initial ophthalmic examination were within normal limits. Over the next month, he developed a seventh nerve palsy, unilateral decreased visual acuity, and bilateral multifocal choroidal infiltrates. The patient was diagnosed with systemic sarcoidosis secondary to tumor necrosis factor alpha (TNFα) inhibitor use after a hilar lymph node biopsy. Upon treatment with high-dose oral corticosteroids, the patient's symptoms and choroidal lesions significantly improved.

conclusionThis case report illustrates a rare presentation of ocular, neurologic, and systemic sarcoidosis presenting as a bilateral multifocal choroiditis and seventh nerve paresis in a patient treated with adalimumab. We highlight the importance of obtaining an ophthalmic evaluation in the management of this rare adverse effect of TNFα inhibitors.

Indexed as

AdalimumabDrug reactionMultifocal choroiditisSarcoidosisTumor necrosis factor alpha inhibitorUveitis

Identifiers

PMID34409234
PMCPMC8365578
OpenAlexW3185258534

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.