Evidence map›Paper›PMID 34409224›Full record

ArticleJournal of current ophthalmology

Low-Level Laser Therapy with 670 nm Alleviates Diabetic Retinopathy in an Experimental Model.

Salwa Abdelkawi Ahmed, Dina Fouad Ghoneim, Mona Ebrahim Morsy, Aziza Ahmed Hassan, Abdel Rahman Hassan Mahmoud

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of current ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Therapeutic Potential of Photobiomodulation for Chronic Kidney Disease.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Salwa Abdelkawi AhmedDepartment of Vision Science, Biophysics and Laser Science Unit, Research Institute of Ophthalmology, Giza, Egypt.
Dina Fouad GhoneimDepartment of Medical Application of Laser, Ophthalmic Unit, National Institute of Laser Enhanced Science, Cairo University, Giza, Egypt.
Mona Ebrahim MorsyDepartment of Medical Application of Laser, Photobiology Unit, National Institute of Laser Enhanced Science, Cairo University, Giza, Egypt.
Aziza Ahmed HassanDepartment of Medical Application of Laser, Ophthalmic Unit, National Institute of Laser Enhanced Science, Cairo University, Giza, Egypt.
Abdel Rahman Hassan MahmoudDepartment of Medical Application of Laser, Ophthalmic Unit, National Institute of Laser Enhanced Science, Cairo University, Giza, Egypt.
Research Institute of Ophthalmology · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effects of low-level laser therapy (LLLT) on the retina with diabetic retinopathy (DR).

methodsEight Wistar rats were used as a control group, and 64 rats were injected intraperitoneally with 55 mg/kg of streptozotocin to induce diabetes and served as a diabetic group. After the establishment of the DR, the rats were separated into (a) 32 rats with DR; did not receive any treatment, (b) 32 rats with DR were exposed to 670 nm LLLT for 6 successive weeks (2 sessions/week). The retinal protein was analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, total antioxidant capacity (TAC), hydrogen peroxide (H

resultsLLLT improved retinal proteins such as neurofilament (NF) proteins (200 KDa, 160 KDa, and 86 KDa), neuron-specific enolase (NSE) (46 KDa). Moreover, the percentage changes in TAC were 46.8% (

conclusionLLLT could modulate retinal proteins such as NSE and NFs, improve the RGCs, photoreceptors, and reduce the oxidative stress that originated in the retina from diabetes-induced DR.

Indexed as

Diabetic retinopathyHydrogen peroxideLow-level laser therapyRetinal proteinTotal antioxidant capacity

Identifiers

PMID34409224
PMCPMC8365584
OpenAlexW3184270546

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.