Evidence map›Paper›PMID 34409196›Full record

ArticleAmerican journal of ophthalmology case reports2021

Epstein-Barr virus induced post-transplant lymphoproliferative disorder presenting with unilateral retinal involvement.

Mainguy Adam, Philippakis Elise, Aurélien Sutra Del Galy, Stanescu-Segall Dinu, Tadayoni Ramin, Bodaghi Bahram, Bonnin Sophie, Touhami Sara

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mainguy AdamDepartment of Ophthalmology, Centre Hospitalo-Universitaire de Nantes, Université de Nantes, France.
Philippakis EliseDepartment of Ophthalmology, Lariboisière University Hospital, Université de Paris, Paris, France.
Aurélien Sutra Del GalyHematology - Transplantation, Saint Louis University Hospital, Université de Paris, Paris, France.
Stanescu-Segall DinuDepartment of Ophthalmology, Reference Center in Rare Diseases, Pitié Salpêtrière University Hospital, Sorbonne Université, Paris, France.
Tadayoni RaminDepartment of Ophthalmology, Lariboisière University Hospital, Université de Paris, Paris, France.
Bodaghi BahramDepartment of Ophthalmology, Reference Center in Rare Diseases, Pitié Salpêtrière University Hospital, Sorbonne Université, Paris, France.
Bonnin SophieDepartment of Ophthalmology, Reference Center in Rare Diseases, Pitié Salpêtrière University Hospital, Sorbonne Université, Paris, France.
Touhami SaraDepartment of Ophthalmology, Reference Center in Rare Diseases, Pitié Salpêtrière University Hospital, Sorbonne Université, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePost-transplant lymphoproliferative disorder (PTLD) represents a spectrum of disorders associated with Epstein Barr Virus infection in up to 80% of cases in the setting of pharmacologic immunosuppression following hematopoietic stem cell or solid organ transplantation. Ocular involvement is a rare finding in PTLD. OBSERVATION: We report the case of a 38-year-old man who presented with unilateral retinal infiltrates as first manifestation of PTLD relapse. Diagnosis relied on the presence of EBV DNA in anterior chamber fluids and vitrectomy that showed the presence of a B cell clone. Systemic relapse of PTLD was detected 12 weeks after retinal findings. Treatment of ocular disease included systemic injections of rituximab and intravitreal injections of methotrexate, halting the extension of retinal infiltrates.

conclusionOcular involvement in PTLD is rare and needs to be acknowledged because it can precede a systemic relapse of the hematological condition.

Indexed as

Epstein-Barr virusMasquerade syndromePost-transplant lymphoproliferative disorderRetinal infiltration

Identifiers

PMID34409196
PMCPMC8361285

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.