Evidence map›Paper›PMID 34409061›Full record

ArticleFrontiers in nutrition2021

Altered Serum Immunological and Biochemical Parameters and Microbiota Composition in Patients With AN During Realimentation.

Radka Roubalova, Petra Prochazkova, Jiri Dvorak, Martin Hill, Hana Papezova, Jakub Kreisinger, Josef Bulant, Alena Lambertova, Petra Holanova, Martin Bilej and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Radka RoubalovaLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
Petra ProchazkovaLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
Jiri DvorakLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
Martin HillDepartment of Steroids and Proteohormones, Institute of Endocrinology, Prague, Czechia.
Hana PapezovaDepartment of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.
Jakub KreisingerDepartment of Zoology, Faculty of Science, Charles University, Prague, Czechia.
Josef BulantDepartment of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.
Alena LambertovaDepartment of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.
Petra HolanovaDepartment of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czechia.
Martin BilejLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
Helena Tlaskalova-HogenovaLaboratory of Cellular and Molecular Immunology, Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia.
Czech Academy of Sciences, Institute of Microbiology · CZCharles University · CZGeneral University Hospital in Prague · CZInstitute of Endocrinology · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anorexia nervosa (AN) is a life-threatening psychiatric disorder with not well-described pathogenesis. Besides the genetic and sociological factors, autoimmunity is also considered to take part in AN pathogenesis. We evaluated general serological factors showing the physiological state of 59 patients with AN at hospital admission and their discharge. We detected the altered levels of some general biochemical and immunological parameters. We also detected decreased levels of appetite-regulating alpha-melanocyte stimulating hormone (α-MSH) in patients at hospital admission. Moreover, elevated anti-α-MSH IgM levels and decreased anti-α-MSH IgA levels were observed in patients with AN. Therefore, we analyzed the gut microbiota composition with special focus on α-MSH antigen-mimetic containing microbes from the

Indexed as

alpha-melanocyte stimulating hormoneanorexia nervosaautoantibodyEnterobacteriaceaeimmune systemmicrobiotarealimentation

Identifiers

PMID34409061
PMCPMC8365021
OpenAlexW3191771273

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.