Evidence map›Paper›PMID 34409026›Full record

ArticleFrontiers in cell and developmental biology2021

Insights Into the Mechanisms of Brain Endothelial Erythrophagocytosis.

Jiahong Sun, Prema Vyas, Samar Mann, Annlia Paganini-Hill, Ane C F Nunes, Wei Ling Lau, David H Cribbs, Mark J Fisher, Rachita K Sumbria

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Cardiovascular Toxicity of Metal-Based Nanoparticles.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Review
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  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jiahong SunDepartment of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA, United States.
Prema VyasHenry E. Riggs School of Applied Life Sciences, Keck Graduate Institute, Claremont, CA, United States.
Samar MannPitzer College, Claremont, CA, United States.
Annlia Paganini-HillDepartments of Neurology and Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, United States.
Ane C F NunesDivision of Nephrology, Department of Medicine, University of California, Irvine, Irvine, CA, United States.
Wei Ling LauDivision of Nephrology, Department of Medicine, University of California, Irvine, Irvine, CA, United States.
David H CribbsInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, United States.
Mark J FisherDepartments of Neurology and Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, United States.
Rachita K SumbriaDepartment of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, CA, United States.
University of California, Irvine · USChapman University · USKeck Graduate Institute · USPitzer College · US

Funding

HEMORHOLOGICAL FACTORS IN CEREBRAL ISCHEMIAR01NS020989 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CRIBBS, DAVID HASTINGS, FISHER, MARK J · 1985 to 2022
$9.1M
A Brain Penetrating Bi-functional Transferrin Receptor Antibody-TNF-alpha Decoy Receptor Fusion Protein for Alzheimer's DiseaseR01AG062840 · NIA · KECK GRADUATE INST OF APPLIED LIFE SCIS · PI SUMBRIA, RACHITA · 2019 to 2024
$1.9M
NIA NIH HHS R01 AG062840NINDS NIH HHS R01 NS020989
6 · The paper itself

Abstract

The endothelial cells which form the inner cellular lining of the vasculature can act as non-professional phagocytes to ingest and remove emboli and aged/injured red blood cells (RBCs) from circulation. We previously demonstrated an erythrophagocytic phenotype of the brain endothelium for oxidatively stressed RBCs with subsequent migration of iron-rich RBCs and RBC degradation products across the brain endothelium

Indexed as

brain endothelial erythrophagocytosiscerebral microhemorrhagesiron depositsoxidative stressphosphatidylserinered blood cell

Identifiers

PMID34409026
PMCPMC8365766
OpenAlexW3191277162

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.