Evidence map›Paper›PMID 34408979›Full record

ArticleFrontiers in oncology2021

Radiomics-Based Texture Analysis of

Charlotte Atkinson, Balaji Ganeshan, Raymond Endozo, Simon Wan, Matthew D Aldridge, Ashley M Groves, Jamshed B Bomanji, Mark N Gaze

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Texture analysis of [European journal of nuclear medicine and molecular imaging · 2026
    Observational
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    Article
  12. Review
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  14. Review
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  17. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Charlotte AtkinsonDepartments of Oncology and Nuclear Medicine, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Balaji GaneshanInstitute of Nuclear Medicine, University College London, London, United Kingdom.
Raymond EndozoInstitute of Nuclear Medicine, University College London, London, United Kingdom.
Simon WanDepartments of Oncology and Nuclear Medicine, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Matthew D AldridgeDepartments of Oncology and Nuclear Medicine, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Ashley M GrovesInstitute of Nuclear Medicine, University College London, London, United Kingdom.
Jamshed B BomanjiDepartments of Oncology and Nuclear Medicine, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Mark N GazeDepartments of Oncology and Nuclear Medicine, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
University College London · GBUniversity College London Hospitals NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNeuroendocrine tumors (NET) are rare cancers with variable behavior. A better understanding of prognosis would aid individualized management. The aim of this hypothesis-generating pilot study was to investigate the prognostic potential of tumor heterogeneity and tracer avidity in NET using texture analysis (TA) of

methodsThe pretherapy

resultsMeasures of heterogeneity (higher kurtosis, higher entropy, and lower skewness) on coarse-texture scale CT and unfiltered PET images predicted shorter PFS (CT coarse kurtosis: p=0.05, PET entropy: p=0.01, PET skewness: p=0.03) and shorter OS (CT coarse kurtosis: p=0.05, PET entropy: p=0.01, PET skewness p=0.02). Conventional PET parameters such as SUV

conclusionThese preliminary data generate a hypothesis that radiomic analysis of neuroendocrine cancer on

Indexed as

177Lu-DOTATATE molecular radiotherapy68Ga-DOTATATE PET/CTneuroendocrine tumor (NET)prognostic biomarkerradiomicstexture analysis

Identifiers

PMID34408979
PMCPMC8366561
OpenAlexW3187641479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.