Evidence map›Paper›PMID 34408969›Full record

ArticleToxicology reports2021

A critical assessment of the estrogenic potency of benzyl salicylate.

Andreas Natsch, Lu Hostettler, Tina Haupt, Heike Laue

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Andreas NatschFragrances S&T, Ingredients Research, Givaudan Schweiz AG, CH-8310 Kemptthal, Switzerland.
Lu HostettlerFragrances S&T, Ingredients Research, Givaudan Schweiz AG, CH-8310 Kemptthal, Switzerland.
Tina HauptFragrances S&T, Ingredients Research, Givaudan Schweiz AG, CH-8310 Kemptthal, Switzerland.
Heike LaueFragrances S&T, Ingredients Research, Givaudan Schweiz AG, CH-8310 Kemptthal, Switzerland.
Givaudan (Switzerland) · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Benzyl salicylate (BS) is a natural ingredient of essential oils and a widely used fragrance chemical. A number of

Indexed as

4−OHT, 4-hydroxy-tamoxifenATCC, American Type Culture CollectionBenzyl salicylateBPA, Bisphenol ABS, Benzyl salicylateCAT, chloramphenicol acetyl transferase geneCoRAP, Community Rolling Action PlanDMEM, Dulbecco's Modified Eagle MediumDMSO, Dimethyl sulfoxideE2, 17β-estradiolERE, estrogen response elementER, estrogen receptorEstrogen receptorFBS, foetal bovine serumHEPES, N-2-hydroxyethylpiperazine-N-ethanesulfonic acidHRPT, Human Relevant Potency ThresholdMCF7 proliferation assayMoA, Mode of actionNOAEL, no observed adverse effect levelOECD, Organisation of Economic Co-operation and DevelopmentPotencyREACH, Registration, Evaluation, Authorisation and Restriction of ChemicalsReporter assaySCCS, European Scientific Committee for Consumer Safety: SRB, sulforhodamine BSubstance evaluationTG, test guidelineYES, Yeast Estrogen screen

Identifiers

PMID34408969
PMCPMC8363597
OpenAlexW3158107133

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.