Evidence map›Paper›PMID 34408920›Full record

ArticleOncoimmunology2021

Modeling

Hannah M Knochelmann, Amalia M Rivera-Reyes, Megan M Wyatt, Aubrey S Smith, Reilley Chamness, Connor J Dwyer, Michael Bobian, Guillermo O Rangel Rivera, Joshuva D Horton, Michael Lilly and 5 more

Abstract read
In one paragraph

Article in Oncoimmunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hannah M KnochelmannDepartment of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0003-0644-123X
Amalia M Rivera-ReyesDivision of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
Megan M WyattDivision of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.
Aubrey S SmithDepartment of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Reilley ChamnessDepartment of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Connor J DwyerDepartment of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Michael BobianDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Guillermo O Rangel RiveraDepartment of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.
Joshuva D HortonDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Michael LillyDepartment of Medicine, Division of Hematology & Oncology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USA.
Martin J RomeoHollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USA.
Cynthia D TimmersHollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USA.
Mark P RubinsteinDepartment of Internal Medicine, Pelotonia Institute of Immuno-Oncology, the Ohio State University, Columbus, ohio, USA.
David M NeskeyDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Chrystal M PaulosDepartment of Microbiology & Immunology, Medical University of South Carolina, Charleston, South Carolina, USA.

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
T-COHR: Training in Craniofacial and Oral Health ResearchT32DE017551 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI YAO, HAI · 2006 to 2025
$10.3M
TRAINING PROGRAM FOR MEDICAL SCIENTISTST32GM008716 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DEMORE, NANCY · 1999 to 2024
$9.3M
Lymphocyte and inflammatory cytokine markers of response in the first-in-human combination of anti-PD-1 mAb and IL-15/IL-15Ra complexes and investigation of mediators of anti-tumor immune responsesR01CA222817 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RUBINSTEIN, MARK P, WRANGLE, JOHN M. · 2019 to 2023
$2.0M
Mechanisms of durable antitumor immunity via CD26hiCD4+ T cellsR01CA208514 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PAULOS, CHRYSTAL MARY · 2016 to 2020
$1.7M
Costimulatory mechanisms of antitumor Th17 cell immunityR01CA175061 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PAULOS, CHRYSTAL MARY · 2013 to 2017
$1.5M
Program in Immunology Research and Entrepreneurship (PIRE)T32AI132164 · NIAID · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TOMLINSON, STEPHEN · 2017 to 2021
$1.2M
Research Specialist Support of a Well-Established Cancer Immunotherapy Research Program Focused on Improving Adoptive T Cell Therapy (ACT)R50CA233168 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI WYATT, MEGAN M · 2018 to 2022
$532k
The role of DCLK1 in the initiation of pancreatic ductal adenocarcinoma and colorectal cancerR50CA233186 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI QU, DONGFENG · 2018 to 2022
$448k
Defining the Role of CD26 in Checkpoint Blockaded Induced Tumor ImmunityR21DE029592 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI NESKEY, DAVID M., PAULOS, CHRYSTAL MARY · 2020 to 2021
$411k
The tumor suppressor capability of p53 is dependent on Non-muscle Myosin IIA function in Head and Neck Cancer.K08DE026542 · NIDCR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI NESKEY, DAVID M. · 2016 to 2018
$405k
NCATS NIH HHS UL1 TR001450NCI NIH HHS F30 CA243307NCI NIH HHS F31 CA232646NCI NIH HHS P30 CA138313NCI NIH HHS R01 CA175061NCI NIH HHS R01 CA208514NCI NIH HHS R01 CA222817NCI NIH HHS R50 CA233168NCI NIH HHS R50 CA233186NIAID NIH HHS T32 AI132164NIDCR NIH HHS K08 DE026542NIDCR NIH HHS R21 DE029592NIDCR NIH HHS T32 DE017551NIGMS NIH HHS T32 GM008716
6 · The paper itself

Abstract

Adoptive transfer of tumor-infiltrating lymphocytes (TIL) elicits the regression of metastatic malignancies, yet a low proportion of patients achieve complete durable responses. The high incidence of relapse in these patients highlights the need to better understand mechanisms of tumor escape from T cell control. While melanoma has provided the foundation for developing TIL therapy, much less is known about TIL efficacy and relapse in other malignancies. We sought to investigate TIL characteristics in mouse tumors which have not been studied in this setting. Here, we expanded murine TIL

Indexed as

Lymphocytes, Tumor-InfiltratingMelanomaAnimalsHumansImmunotherapy, AdoptiveLymphocytesMiceNeoplasm Recurrence, LocalACTAdoptive T cell therapysolid tumorsT cellTIL therapytumor-infiltrating lymphocyte

Identifiers

PMID34408920
PMCPMC8366547

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.