Evidence map›Paper›PMID 34408909›Full record

ArticleRegenerative biomaterials2021

3D bioprinting of conductive hydrogel for enhanced myogenic differentiation.

Ying Wang, Qingshuai Wang, Shengchang Luo, Zhoujiang Chen, Xiang Zheng, Ranjith Kumar Kankala, Aizheng Chen, Shibin Wang

Abstract read
In one paragraph

Article in Regenerative biomaterials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  5. Graphene and TiACS applied bio materials · 2026
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  8. Article
  9. Article
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  13. Heterogeneous and Composite Bioinks for 3D-Bioprinting of Complex Tissue.Biomedical materials & devices (New York, N.Y.) · 2025
    Review
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ying WangInstitute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, P. R. China.ORCID https://orcid.org/0000-0001-6749-3848
Qingshuai WangInstitute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, P. R. China.
Shengchang LuoInstitute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, P. R. China.
Zhoujiang ChenInstitute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, P. R. China.
Xiang ZhengInstitute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, P. R. China.
Ranjith Kumar KankalaInstitute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, P. R. China.ORCID https://orcid.org/0000-0003-4081-9179
Aizheng ChenInstitute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, P. R. China.ORCID https://orcid.org/0000-0002-5840-3406
Shibin WangInstitute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, hydrogels have gained enormous interest in three-dimensional (3D) bioprinting toward developing functional substitutes for tissue remolding. However, it is highly challenging to transmit electrical signals to cells due to the limited electrical conductivity of the bioprinted hydrogels. Herein, we demonstrate the 3D bioprinting-assisted fabrication of a conductive hydrogel scaffold based on poly-3,4-ethylene dioxythiophene (PEDOT) nanoparticles (NPs) deposited in gelatin methacryloyl (GelMA) for enhanced myogenic differentiation of mouse myoblasts (C2C12 cells). Initially, PEDOT NPs are dispersed in the hydrogel uniformly to enhance the conductive property of the hydrogel scaffold. Notably, the incorporated PEDOT NPs showed minimal influence on the printing ability of GelMA. Then, C2C12 cells are successfully encapsulated within GelMA/PEDOT conductive hydrogels using 3D extrusion bioprinting. Furthermore, the proliferation, migration and differentiation efficacies of C2C12 cells in the highly conductive GelMA/PEDOT composite scaffolds are demonstrated using various

Indexed as

3D bioprintingconductive hydrogelelectrical stimulationmyoblastsmyogenic differentiation

Identifiers

PMID34408909
PMCPMC8363764

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.