Evidence map›Paper›PMID 34408746›Full record

ArticleFrontiers in immunology2021

Activated, Pro-Inflammatory Th1, Th17, and Memory CD4+ T Cells and B Cells Are Involved in Delayed-Type Hypersensitivity Arthritis (DTHA) Inflammation and Paw Swelling in Mice.

Gaoyang Li, Shrikant Shantilal Kolan, Shuai Guo, Katarzyna Marciniak, Pratibha Kolan, Giulia Malachin, Franco Grimolizzi, Guttorm Haraldsen, Bjørn Steen Skålhegg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Gaoyang LiDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Shrikant Shantilal KolanDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Shuai GuoDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Katarzyna MarciniakDepartment of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway.
Pratibha KolanDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Giulia MalachinDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Franco GrimolizziDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Guttorm HaraldsenDepartment of Pathology, Oslo University Hospital and University of Oslo, Oslo, Norway.
Bjørn Steen SkålheggDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
University of Oslo · NOOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Delayed-type hypersensitivity arthritis (DTHA) is a recently established experimental model of rheumatoid arthritis (RA) in mice with pharmacological values. Despite an indispensable role of CD4+ T cells in inducing DTHA, a potential role for CD4+ T cell subsets is lacking. Here we have quantified CD4+ subsets during DTHA development and found that levels of activated, pro-inflammatory Th1, Th17, and memory CD4+ T cells in draining lymph nodes were increased with differential dynamic patterns after DTHA induction. Moreover, according to B-cell depletion experiments, it has been suggested that this cell type is not involved in DTHA. We show that DTHA is associated with increased levels of B cells in draining lymph nodes accompanied by increased levels of circulating IgG. Finally, using the anti-rheumatoid agents, methotrexate (MTX) and the anti-inflammatory drug dexamethasone (DEX), we show that MTX and DEX differentially suppressed DTHA-induced paw swelling and inflammation. The effects of MTX and DEX coincided with differential regulation of levels of Th1, Th17, and memory T cells as well as B cells. Our results implicate Th1, Th17, and memory T cells, together with activated B cells, to be involved and required for DTHA-induced paw swelling and inflammation.

Indexed as

AllergensAnimalsAntibodiesArthritis, ExperimentalB-LymphocytesCD4-Positive T-LymphocytesCells, CulturedFemaleFootHypersensitivity, DelayedImmunologic MemoryLymph NodesMiceMice, Inbred C57BLSerum Albumin, BovineSpleenAllergensAntibodiesSerum Albumin, BovineCD4+ T celldexamethasoneDTHA mouse modelmethotrexaterheumatoid arthritis

Identifiers

PMID34408746
PMCPMC8365304
OpenAlexW3187344277

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.