Evidence map›Paper›PMID 34408743›Full record

ArticleFrontiers in immunology2021

Fast and Efficient Genome Editing of Human FOXP3

Lauren Van Zeebroeck, Rebeca Arroyo Hornero, Beatriz F Côrte-Real, Ibrahim Hamad, Torsten B Meissner, Markus Kleinewietfeld

Open access · goldAbstract readValidation Study
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. CAR-mediated release of IL-10 increases the function of regulatory T cells: Relevance for future clinical application.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
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  12. IL-2-based approaches to Treg enhancement.Clinical and experimental immunology · 2023
    Review
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  16. Dissecting the role ofFrontiers in immunology · 2022
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Lauren Van ZeebroeckVlaams Instituut voor Biotechnologie (VIB) Laboratory of Translational Immunomodulation, Vlaams Instituut voor Biotechnologie (VIB) Center for Inflammation Research (IRC), Hasselt University, Diepenbeek, Belgium.
Rebeca Arroyo HorneroVlaams Instituut voor Biotechnologie (VIB) Laboratory of Translational Immunomodulation, Vlaams Instituut voor Biotechnologie (VIB) Center for Inflammation Research (IRC), Hasselt University, Diepenbeek, Belgium.
Beatriz F Côrte-RealVlaams Instituut voor Biotechnologie (VIB) Laboratory of Translational Immunomodulation, Vlaams Instituut voor Biotechnologie (VIB) Center for Inflammation Research (IRC), Hasselt University, Diepenbeek, Belgium.
Ibrahim HamadVlaams Instituut voor Biotechnologie (VIB) Laboratory of Translational Immunomodulation, Vlaams Instituut voor Biotechnologie (VIB) Center for Inflammation Research (IRC), Hasselt University, Diepenbeek, Belgium.
Torsten B MeissnerDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.
Markus KleinewietfeldVlaams Instituut voor Biotechnologie (VIB) Laboratory of Translational Immunomodulation, Vlaams Instituut voor Biotechnologie (VIB) Center for Inflammation Research (IRC), Hasselt University, Diepenbeek, Belgium.
Vlaams Instituut voor Biotechnologie · BEBeth Israel Deaconess Medical Center · USHasselt University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FOXP3

Indexed as

Blood Buffy CoatCRISPR-Cas SystemsForkhead Transcription FactorsGene EditingGene Knockdown TechniquesHealthy VolunteersHEK293 CellsHumansImmunotherapy, AdoptiveInterleukin-2 Receptor alpha SubunitPrimary Cell CultureReceptors, Interleukin-6RNA, Guide, CRISPR-Cas SystemsTime FactorsT-Lymphocytes, RegulatoryForkhead Transcription FactorsFOXP3 protein, humanIL2RA protein, humanIL6R protein, humanInterleukin-2 Receptor alpha SubunitReceptors, Interleukin-6RNA, Guide, CRISPR-Cas SystemsautoimmunityCD4COVID-19CRISPRgenome editinghumanIL6Rregulatory T cell

Identifiers

PMID34408743
PMCPMC8365355
OpenAlexW3192636910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.