Evidence map›Paper›PMID 34408668›Full record

ArticleFrontiers in physiology2021

Upregulation of Calcium Homeostasis Modulators in Contractile-To-Proliferative Phenotypical Transition of Pulmonary Arterial Smooth Muscle Cells.

Marisela Rodriguez, Jiyuan Chen, Pritesh P Jain, Aleksandra Babicheva, Mingmei Xiong, Jifeng Li, Ning Lai, Tengteng Zhao, Moises Hernandez, Angela Balistrieri and 10 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Marisela RodriguezSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, La Jolla, CA, United States.
Jiyuan ChenSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, La Jolla, CA, United States.
Pritesh P JainSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, La Jolla, CA, United States.
Aleksandra BabichevaSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, La Jolla, CA, United States.
Mingmei XiongSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, La Jolla, CA, United States.
Jifeng LiSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, La Jolla, CA, United States.
Ning LaiSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, La Jolla, CA, United States.
Tengteng ZhaoSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, La Jolla, CA, United States.
Moises HernandezDivision of Cardiothoracic Surgery, Department of Surgery, La Jolla, CA, United States.
Angela BalistrieriSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, La Jolla, CA, United States.
Sophia ParmisanoSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, La Jolla, CA, United States.
Tatum SimonsonSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, La Jolla, CA, United States.
Ellen BreenSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, La Jolla, CA, United States.
Daniela Valdez-JassoDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, United States.
Patricia A ThistlethwaiteDivision of Cardiothoracic Surgery, Department of Surgery, La Jolla, CA, United States.
John Y-J ShyyDivision of Cardiovascular Medicine, Department of Medicine, La Jolla, CA, United States.
Jian WangSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, La Jolla, CA, United States.
Joe G N GarciaDepartment of Medicine, The University of Arizona, Tucson, AZ, United States.
Ayako MakinoDivision of Endocrinology and Metabolism, La Jolla, CA, United States.
Jason X-J YuanSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, La Jolla, CA, United States.
First Affiliated Hospital of Guangzhou Medical University · CNCapital Medical University · CNUniversity of Arizona · USUniversity of California San Diego · US

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
Ion Channels and Membrane Receptors in Pulmonary Arterial HypertensionR35HL135807 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YUAN, JASON X J · 2017 to 2023
$5.6M
Novel Involvement of NAMPT and TLR4 in PAH Vascular RemodelingR01HL141387 · NHLBI · UNIVERSITY OF FLORIDA · PI Joe G. N. Garcia, Ayako Makino · 2019 to 2026
$3.8M
UCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3M
Molecular Mechanisms of Pulmonary HypertensionR01HL070852 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THISTLETHWAITE, PATRICIA A · 2002 to 2011
$3.1M
Multiscale Modeling of Right Ventricular Fibrotic Remodeling in Pulmonary Arterial HypertensionR01HL155945 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VALDEZ-JASSO, DANIELA · 2021 to 2025
$1.9M
Role of Gap Junction in Hypoxia-induced Pulmonary HypertensionR01HL146764 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAKINO, AYAKO · 2019 to 2022
$1.6M
Replacement of Small Animal Echocardiographic InstrumentationS10OD010417 · OD · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI ROSS, ROBERT SCOTT · 2012 to 2012
$371k
NHLBI NIH HHS R01 HL070852NHLBI NIH HHS R01 HL141387NHLBI NIH HHS R01 HL146764NHLBI NIH HHS R01 HL155945NHLBI NIH HHS R25 HL145817NHLBI NIH HHS R35 HL135807NHLBI NIH HHS T32 HL007444NIEHS NIH HHS P30 ES006694NIH HHS S10 OD010417
6 · The paper itself

Abstract

Excessive pulmonary artery (PA) smooth muscle cell (PASMC) proliferation and migration are implicated in the development of pathogenic pulmonary vascular remodeling characterized by concentric arterial wall thickening and arteriole muscularization in patients with pulmonary arterial hypertension (PAH). Pulmonary artery smooth muscle cell contractile-to-proliferative phenotypical transition is a process that promotes pulmonary vascular remodeling. A rise in cytosolic Ca

Indexed as

CALHM channelscontractile-to-proliferativephenotypical transitionpulmonary hypertensionsmooth muscle cell

Identifiers

PMID34408668
PMCPMC8364962
OpenAlexW3191393042

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.