Evidence map›Paper›PMID 34408655›Full record

ArticleFrontiers in physiology2021

Synaptic Components, Function and Modulation Characterized by GCaMP6f Ca

Joseph F Margiotta, Kristen M Smith-Edwards, Andrea Nestor-Kalinoski, Brian M Davis, Kathryn M Albers, Marthe J Howard

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Calcium image analysis in the moving gut.Neurogastroenterology and motility · 2023
    Article
  3. The enteric nervous system.Physiological reviews · 2023
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joseph F MargiottaDepartment of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States.
Kristen M Smith-EdwardsDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Andrea Nestor-KalinoskiDepartment of Surgery, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States.
Brian M DavisDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Kathryn M AlbersDepartment of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Marthe J HowardDepartment of Neurosciences, College of Medicine and Life Sciences, University of Toledo, Toledo, OH, United States.
University of Pittsburgh · USUniversity of Toledo · US

Funding

Anatomical-Functional Mapping of Enteric Neural CircuitsOT2OD023859 · OD · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI HOWARD, MARTHE J · 2016 to 2019
$6.9M
Molecular and Functional Analysis of Hirschsprung Defects in Humans and MouseR01DK122798 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERS, KATHRYN MARIE, DAVIS, BRIAN M · 2020 to 2023
$2.8M
Tool Building to Inform Structure-Functions relationships in the Autonomic Nervous SystemU18EB021790 · NIBIB · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI HOWARD, MARTHE J · 2015 to 2016
$473k
Identifying Defects in the ENS Connectome of Hirschsprung Disease ModelsF32DK120115 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SMITH-EDWARDS, KRISTEN MICHELLE · 2019 to 2021
$156k
NIBIB NIH HHS U18 EB021790NIDDK NIH HHS F32 DK120115NIDDK NIH HHS R01 DK122798NIH HHS OT2 OD023859
6 · The paper itself

Abstract

The peristaltic contraction and relaxation of intestinal circular and longitudinal smooth muscles is controlled by synaptic circuit elements that impinge upon phenotypically diverse neurons in the myenteric plexus. While electrophysiological studies provide useful information concerning the properties of such synaptic circuits, they typically involve tissue disruption and do not correlate circuit activity with biochemically defined neuronal phenotypes. To overcome these limitations, mice were engineered to express the sensitive, fast Ca

Indexed as

ionotropic serotonin receptor (5-HT3R)mousemyentericnicotinic acetylcholine receptor (nAChR)synapse

Identifiers

PMID34408655
PMCPMC8365335
OpenAlexW3190995176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.