Evidence map›Paper›PMID 34408610›Full record

ArticleJournal of Taibah University Medical Sciences2021

Light-cured hyaluronic acid composite hydrogels using riboflavin as a photoinitiator for bone regeneration applications.

Mohamed M Abdul-Monem, Elbadawy A Kamoun, Dawlat M Ahmed, Esmail M El-Fakharany, Fayza H Al-Abbassy, Hanaa M Aly

Abstract read
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In one paragraph

Article in Journal of Taibah University Medical Sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohamed M Abdul-MonemDental Biomaterials Department, Faculty of Dentistry, Alexandria University, Egypt.
Elbadawy A KamounPolymeric Materials Research Department, Advanced Technology and New Materials Research Institute, City of Scientific Research and Technological Applications, Egypt.
Dawlat M AhmedDental Biomaterials Department, Faculty of Dentistry, Alexandria University, Egypt.
Esmail M El-FakharanyProtein Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications, Egypt.
Fayza H Al-AbbassyDental Biomaterials Department, Faculty of Dentistry, Alexandria University, Egypt.
Hanaa M AlyOral Biology Department, Faculty of Dentistry, Alexandria University, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSelf-healing of bone from damage caused by infection, trauma, or surgical removal of cysts is limited. Generally, external intervention is needed to increase bone repair and regeneration. In this study, biocompatible light-cured hyaluronic acid hydrogels loaded with nano-hydroxyapatite and chitosan were prepared using a new photoinitiating system based on riboflavin for bone regeneration applications.

methodFour light-cured hydrogel groups were prepared as follows: Group I, a control group with no additions; Group II, loaded with nano-hydroxyapatite; Group III, loaded with chitosan; and Group IV, loaded with both nano-hydroxyapatite and chitosan. The new photoinitiating system consisted of riboflavin as a photoinitiator, dimethylaminoethyl methacrylate (DMAEMA) as a coinitiator (being used with riboflavin for the first time), and diphenyliodonium chloride as an accelerator. For each group, X-ray-diffraction, surface morphology by scanning electron microscope, mechanical properties, water uptake (%), and cell viability (%) were tested. The osteogenic potential was then tested in a rabbit model, and histomorphometric assessment was conducted.

resultsIn the four groups, the light-cured hydrogels were obtained after a short irradiation time of 10 s using a dental light-curing unit. The prepared hydrogels were biocompatible. Simultaneous addition of nano-hydroxyapatite and chitosan increased the mechanical properties threefold and the osteogenic potential, twofold, with a statistically significant difference compared with the control group.

conclusionsLight-cured hyaluronic acid composite hydrogels loaded with nano-hydroxyapatite and chitosan-prepared by using the new photoinitiating system-are promising materials that can be used in bone regeneration applications.

Indexed as

Bone regenerationChitosanHyaluronic acid hydrogelLight-curedRiboflavin

Identifiers

PMID34408610
PMCPMC8348264

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.