Evidence map›Paper›PMID 34408544›Full record

ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2021

Jayasinghe Arachchige Nirosha Sandamali, Ruwani Punyakanthi Hewawasam, Kamani Ayoma Perera Wijewardana Jayatilaka, Lakmini Kumari Boralugoda Mudduwa

Open access · hybridAbstract read
In one paragraph

Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Pharmaceuticals (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
  6. Cardioprotective Potential ofCurrent pharmaceutical biotechnology · 2025
    Article
  7. Role of diosmin in preventing doxorubicin-induced cardiac oxidative stress, inflammation, and hypertrophy: A mechanistic approach.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  8. Phenolics Extracted fromMolecules (Basel, Switzerland) · 2023
    Article
  9. Chemical Composition of theAntibiotics (Basel, Switzerland) · 2023
    Article
  10. Article
  11. Aqueous Extract of Cinnamon (Evidence-based complementary and alternative medicine : eCAM · 2023
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jayasinghe Arachchige Nirosha SandamaliDepartment of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Ruhuna, 80000, Sri Lanka.
Ruwani Punyakanthi HewawasamDepartment of Biochemistry, Faculty of Medicine, University of Ruhuna, 80000, Sri Lanka.
Kamani Ayoma Perera Wijewardana JayatilakaDepartment of Biochemistry, Faculty of Medicine, University of Ruhuna, 80000, Sri Lanka.
Lakmini Kumari Boralugoda MudduwaDepartment of Pathology, Faculty of Medicine, University of Ruhuna, 80000, Sri Lanka.
University of Ruhuna · LK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-tumour efficacy of doxorubicin is hindered by the cumulative dose-dependent cardiotoxicity induced by reactive oxygen species during its metabolism. As

Indexed as

ABEC, Aqueous bark extract of Cinnamomum zeylanicumABTS, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)Antioxidant effectAST, Aspartate aminotransferaseCardiotoxicityCinnamomum zeylanicum bark extractcTnI, Cardiac troponin IDNA, Deoxyribonucleic acidDoxorubicinDPPH, 2,2-diphenyl-1-picrylhydrazylELISA, Enzyme-linked immunosorbent assayFRAP, Ferric reducing antioxidant powerGPx, Glutathione peroxidaseGR, Glutathione reductaseGSH, Reduced glutathioneH & E, Haematoxylin and eosinIP, IntraperitonealLDH, Lactate dehydrogenaseMDA, MalondialdehydeMPO, MyeloperoxidaseMyeloperoxidaseNADPH, Nicotinamide adenine dinucleotide phosphate hydrogenNO, Nitric oxideNT-pro BNP, N terminal- pro brain natriuretic peptideOxidative-stressPBS, Phosphate buffered salineROS, Reactive oxygen speciesSOD, Superoxide dismutaseUSA, United States of AmericaWHO, World Health Organization

Identifiers

PMID34408544
PMCPMC8363100
OpenAlexW3174954494

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.