Evidence map›Paper›PMID 34408501›Full record

ReviewInternational journal of women's health2021

Management of Pregnancy in Women of Advanced Maternal Age: Improving Outcomes for Mother and Baby.

Itamar Glick, Ela Kadish, Misgav Rottenstreich

Erratum issued Registry-linked trialAbstract readReview
In one paragraph

Review in International journal of women's health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06528340 (Study of Pregnancies Outcomes in Advanced Maternal Age Women), which is not on this map. Cited by 88 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06528340 completednot on this mapstarted 2025, after this paper: background citation

Study of Pregnancies Outcomes in Advanced Maternal Age Women

Typeobservational_patient_registrySponsorCentro di Ricerca Clinica SalentinoRan2025 to 2026Enrolled1,000ConditionsAdvanced Maternal Age Pregnancy, Premature, Labor Complication, Delivery ComplicationArmsspontaneous delivery
3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Impact of maternal health on neonatal and long-term kidney outcomes.Pediatric nephrology (Berlin, Germany) · 2026
    Review
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  9. Impact of socioeconomic status and remoteness of residence on pregnancy outcome in major congenital heart disease: mediation analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Article
  10. Article
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  16. Review
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  20. Observational

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Itamar GlickDepartment of Obstetrics & Gynecology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Ela KadishFaculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.ORCID 0000-0003-2964-2712
Misgav RottenstreichDepartment of Obstetrics & Gynecology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.ORCID 0000-0003-4875-1455

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy at advanced maternal age (age >35 years old) is considered a risk factor for adverse maternal and perinatal outcomes. Yet, pregnancies of advanced maternal age have become more prevalent over the last few decades. Possible maternal complications of pregnancy at age 35 or older include increased risk of spontaneous miscarriage, preterm labor, gestational diabetes mellitus, pre-eclampsia, stillbirth, chromosomal abnormalities, and cesarean delivery. Possible adverse fetal outcomes include infants small for gestational age and intrauterine growth restrictions, low Apgar score, admission to neonatal intensive care units, and an autism spectrum disorder. This paper aims to present an up-to-date review of the literature, summarizing the most current studies and implications for the management of pregnancy of advanced maternal age.

Indexed as

advanced maternal ageadverse maternal outcomeadverse perinatal outcome

Identifiers

PMID34408501
PMCPMC8364335

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.