ArticleInfection and drug resistance2021
Abnormal Indexes of Liver and Kidney Injury Markers Predict Severity in COVID-19 Patients.
Article in Infection and drug resistance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Accuracy of routine laboratory tests to predict mortality and deterioration to severe or critical COVID-19 in people with SARS-CoV-2.The Cochrane database of systematic reviews · 2024Pooled it
- Meta-analysis of Transcriptomic Data from Lung Autopsy and Cellular Models of SARS-CoV-2 Infection.Biochemical genetics · 2024Pooled it
- Evaluation of Curcumin-Piperine Supplementation in COVID-19 Patients Admitted to the Intensive Care: A Double-Blind, Randomized Controlled Trial.Advances in experimental medicine and biology · 2023Trial
- Impact of Early Administration of Albumin on Mortality Among Severe COVID-19 Patients, China.Infection and drug resistance · 2025Article
- Clinical and Epidemiological Features of Pediatric COVID-19: A Retrospective Study.Health science reports · 2024Article
- Serum calcium level at 32 weeks of gestation could be applied as a predictor of preterm delivery: a retrospective study.European journal of medical research · 2024Article
- In vitro and in vivo validation of the antiviral effect of hCypA against SARS-CoV-2 via binding to the RBD of spike protein.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Crocin protects against endoplasmic reticulum stress-related tubular injury in diabetic nephropathy via the activation of the PI3K/AKT/Nrf2 pathway.Iranian journal of basic medical sciences · 2024Article
- Factors Associated with Mortality Among Severe Omicron Patients for COVID-19.Infection and drug resistance · 2024Article
- The Value of Common Laboratory Markers in Predicting the Severity of COVID-19 Patients.Infection and drug resistance · 2024Article
- Predictors of COVID-19 Severity in Elderly Patients Infected by Omicron in China, 18 December 2022-5 February 2023.Infection and drug resistance · 2023Article
- Observational
- Baseline and early changes in laboratory parameters predict disease severity and fatal outcomes in COVID-19 patients.Frontiers in public health · 2023Article
- Clinical profile, treatment, and outcomes of patients with COVID-19 in a tertiary referral hospital in South Sumatera, Indonesia: A retrospective single-center study.Belitung nursing journal · 2022Article
- A Review of Routine Laboratory Biomarkers for the Detection of Severe COVID-19 Disease.International journal of analytical chemistry · 2022Review
- Steroid initiation timing and outcome of coronavirus disease 2019 patients: A multicenter, retrospective, observational study.International journal of immunopathology and pharmacologyObservational
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Authors and funding
11 authors.
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Abstract
backgroundSARS-CoV-2 can damage not only the lungs but also the liver and kidney. Most critically ill patients with coronavirus disease 2019 (COVID-19) have liver and kidney dysfunction. We aim to investigate the levels of liver and kidney function indexes in mild and severe COVID-19 patients and their capability to predict the severity of the disease.
methodsThe characteristics and laboratory indexes were compared between patients with different conditions. We applied binary logistic regression to find the independent risk factors of severe patients. Receiver operating characteristic (ROC) analysis was used to predict the severity of COVID-19 using the liver and kidney function indexes.
resultsThis study enrolled 266 COVID-19 patients, including 235 mild patients and 31 severe patients. Compared with mild patients, severe patients had lower albumin (ALB) and higher alanine aminotransferase (ALT), aspartate aminotransferase (AST), and urea nitrogen (BUN) (all p<0.001). Binary logistic regression analysis also identified ALB [OR=0.273 (0.079-0.947), p=0.041] and ALT [OR=2.680 (1.036-6.934), p=0.042] as independent factors of severe COVID-19 patients. Combining ALB, ALT, BUN, and LDH exhibited the area under ROC at 0.914, with a sensitivity of 86.7% and specificity of 83.0%.
conclusionCOVID-19 patients, especially severe patients, have damage to liver and kidney function. ALT, AST, LDH, and BUN could be independent factors for predicting the severity of COVID-19. Combining the ALB, ALT, BUN, and LDH could predict the transition from mild to severe in COVID-19 patients.
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