ArticleNeuropsychiatric disease and treatment2021
Associations of C-Reactive Protein, Free Triiodothyronine, Thyroid Stimulating Hormone and Creatinine Levels with Agitation in Patients with Schizophrenia: A Comparative Cross-Sectional Study.
Article in Neuropsychiatric disease and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Shared genetic components between metabolic syndrome and schizophrenia: Genetic correlation using multipopulation data sets.Psychiatry and clinical neurosciences · 2022Pooled it
- Changes of Mental State and Serum Prolactin Levels in Patients with Schizophrenia and Depression after Receiving the Combination Therapy of Amisulpride and Chloroprothixol Tablets.Computational and mathematical methods in medicine · 2022Trial
- Sex-specific associations between thyroid hormones and the severity of positive and negative symptoms in patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Thyroid hormones and cognitive function in chronic schizophrenia: a large-scale cross-sectional study.European archives of psychiatry and clinical neuroscience · 2026Article
- Is There a Link Between TSH Levels and Schizophrenia? A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Correlation analyse between thyroid hormone levels and severity of schizophrenia symptoms.World journal of psychiatry · 2025Article
- A Comprehensive Understanding of Psychomotor Agitation: From Causes to Hospital Care.Current neuropharmacology · 2025Review
- Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia.BMC psychiatry · 2024Article
- Decision tree distinguish affective disorder diagnosis from psychotic disorder diagnosis with clinical and lab factors.Heliyon · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAgitation is prevalent among inpatients with schizophrenia. The aim of this study was to investigate whether biochemical parameters are associated with agitation in schizophrenia. PATIENTS AND
methodsAgitation was evaluated by the Positive and Negative Syndrome Scale-Excited Component questionnaire (PANSS-EC). Fasting serum levels of C-reactive protein (CRP), free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), uric acid (UA), creatinine, glucose and lipids were measured.
resultsThe analysis included 154 inpatients with schizophrenia (71 with agitation, 83 without agitation) and 75 healthy control subjects. Patients with schizophrenia and agitation had higher serum levels of CRP, FT3, FT4 and UA as well as lower levels of serum TSH and creatinine than patients without agitation (all
conclusionIncreased serum CRP and FT3 levels and decreased serum TSH and creatinine levels are independent risk factors for agitation in hospitalized patients with schizophrenia. Inflammation, thyroid hormones and renal function may be involved in the pathogenesis of agitation in schizophrenia.
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