Evidence map›Paper›PMID 34408416›Full record

ReviewInternational journal of nanomedicine2021

Advances and Perspectives in the Use of Carbon Nanotubes in Vaccine Development.

Elidamar Nunes de Carvalho Lima, Ricardo Sobhie Diaz, João Francisco Justo, José Roberto Castilho Piqueira

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
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  7. mRNA vaccines and their delivery strategies: A journey from infectious diseases to cancer.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Review
  8. Review
  9. Article
  10. Review
  11. Micro and nanotechnologies: The little formulations that could.Bioengineering & translational medicine · 2023
    Review
  12. Review
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elidamar Nunes de Carvalho LimaTelecommunication and Control Engineering Department, Polytechnic School of the University of São Paulo, São Paulo, Brazil.
Ricardo Sobhie DiazInfectious Diseases Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil.ORCID 0000-0002-8395-7304
João Francisco JustoElectronic Systems Engineering Department, Polytechnic School of the University of São Paulo, São Paulo, Brazil.
José Roberto Castilho PiqueiraTelecommunication and Control Engineering Department, Polytechnic School of the University of São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advances in nanobiotechnology have allowed the utilization of nanotechnology through nanovaccines. Nanovaccines are powerful tools for enhancing the immunogenicity of a specific antigen and exhibit advantages over other adjuvant approaches, with features such as expanded stability, prolonged release, decreased immunotoxicity, and immunogenic selectivity. We introduce recent advances in carbon nanotubes (CNTs) to induce either a carrier effect as a nanoplatform or an immunostimulatory effect. Several studies of CNT-based nanovaccines revealed that due to the ability of CNTs to carry immunogenic molecules, they can act as nonclassical vaccines, a quality not possessed by vaccines with traditional formulations. Therefore, adapting and modifying the physicochemical properties of CNTs for use in vaccines may additionally enhance their efficacy in inducing a T cell-based immune response. Accordingly, the purpose of this study is to renew and awaken interest in and knowledge of the safe use of CNTs as adjuvants and carriers in vaccines.

Indexed as

Nanotubes, CarbonVaccinesAdjuvants, ImmunologicAntigensNanotechnologyAdjuvants, ImmunologicAntigensNanotubes, CarbonVaccinescarbon nanotubes-CNTscarrier effectfunctionalizationimmunomodulationnanoplatformnanovaccine

Identifiers

PMID34408416
PMCPMC8367085

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.