Evidence map›Paper›PMID 34408336›Full record

ArticleNature reviews. Neuroscience2021

Aquaporin 4 and glymphatic flow have central roles in brain fluid homeostasis.

Mootaz M Salman, Philip Kitchen, Jeffrey J Iliff, Roslyn M Bill

Open access · bronzeAbstract readLetterComment
PubMed Publisher
In one paragraph

Article in Nature reviews. Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 89 citations in OpenAlex.

  1. Article
  2. Review
  3. Adenosine AJournal of neurochemistry · 2026
    Article
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  5. Discovery of Abundant Nano-scale Lymphatic-like Vessels in Brains.bioRxiv : the preprint server for biology · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Mootaz M SalmanDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. mootaz.salman@dpag.ox.ac.uk.ORCID 0000-0002-5683-1706
Philip KitchenSchool of Biosciences, College of Health and Life Sciences, Aston University, Birmingham, UK. p.kitchen1@aston.ac.uk.
Jeffrey J IliffDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA. jiliff@uw.edu.
Roslyn M BillSchool of Biosciences, College of Health and Life Sciences, Aston University, Birmingham, UK. r.m.bill@aston.ac.uk.ORCID 0000-0003-1331-0852
Aston University · GBUniversity of Oxford · GBUniversity of Washington · US

Funding

Role of perivascular aquaporin-4 polarization in post-traumatic neurodegenerationR01NS089709 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI ILIFF, JEFFREY J · 2015 to 2019
$1.7M
NINDS NIH HHS R01 NS089709
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Aquaporin 4BrainHomeostasisHumansAquaporin 4

Identifiers

PMID34408336
OpenAlexW3196253719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.