ArticleNature2021
Cotranslational prolyl hydroxylation is essential for flavivirus biogenesis.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Lost in translation: interferon-stimulated genes targeting flavivirus protein synthesis.Journal of virology · 2026Review
- mSphere of Influence: Host-pathogen interactions-the fascinating world of molecular interplay.mSphere · 2026Article
- Proviral NUP153 binding to viral proteins and RNA regulates structural-nonstructural protein ratios in orthoflavivirus infection.Nature communications · 2026Article
- Binding of Glycyl-tRNA synthetase to Mengovirus RNA stimulates translation.Nucleic acids research · 2026Article
- mRNA poly(A)-tail length is a battleground for coronavirus-host competition.bioRxiv : the preprint server for biology · 2025Article
- The glycoprotein quality control factor Malectin promotes coronavirus replication and viral protein biogenesis.bioRxiv : the preprint server for biology · 2025Article
- Subversion of phosphorylated SR proteins by enterovirus A71 in IRES-dependent translation revealed by RNA-interactome analysis.PLoS pathogens · 2025Article
- Overview of host-directed antiviral targets for future research and drug development.Acta pharmaceutica Sinica. B · 2025Review
- Flaviviruses induce ER-specific remodelling of protein synthesis.PLoS pathogens · 2024Article
- RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages.Molecular cell · 2024Article
- P4HA2 hydroxylates SUFU to regulate the paracrine Hedgehog signaling and promote B-cell lymphoma progression.Leukemia · 2024Article
- The P124A mutation of SRP14 alters its migration on SDS-PAGE without impacting its function.Acta biochimica et biophysica Sinica · 2024Article
- SARS-CoV-2 Nsp1 cooperates with initiation factors EIF1 and 1A to selectively enhance translation of viral RNA.PLoS pathogens · 2024Article
- Nuclear membrane protein SUN2 promotes replication of flaviviruses through modulating cytoskeleton reorganization mediated by NS1.Nature communications · 2024Article
- RAPIDASH: A tag-free enrichment of ribosome-associated proteins reveals compositional dynamics in embryonic tissues and stimulated macrophages.bioRxiv : the preprint server for biology · 2023Article
- Viral Evolution Shaped by Host Proteostasis Networks.Annual review of virology · 2023Review
- Article
- Elusive Trans-Acting Factors Which Operate with Type I (Poliovirus-like) IRES Elements.International journal of molecular sciences · 2022Review
- Article
- Host cytoskeletal vimentin serves as a structural organizer and an RNA-binding protein regulator to facilitate Zika viral replication.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Ranen AvinerDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.
Kathy H LiDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Judith FrydmanDepartment of Biology and Genetics, Stanford University, Stanford, CA, USA. jfrydman@stanford.edu.ORCID http://orcid.org/0000-0003-2302-6943
Raul AndinoDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA. raul.andino@ucsf.edu.ORCID http://orcid.org/0000-0001-5503-9349
University of California, San Francisco · USPediatrics and Genetics · US
Funding
Unbiased Functional Characterization of Enterovirus-Host InteractionsP01AI091575 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDINO, RAUL · 2011 to 2015
$10.5MRNA PROTEIN INTERACTIONS IN POLIOVIRUS REPLICATIONR01AI040085 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDINO, RAUL · 1998 to 2019
$5.8MPROTEIN FOLDING IN THE EUKARYOTIC CYTOSOLR01GM056433 · NIGMS · STANFORD UNIVERSITY · PI Judith Frydman · 1997 to 2026
$5.0MProtein Folding in the Eukaryotic CytosolR37GM056433 · NIGMS · STANFORD UNIVERSITY · PI FRYDMAN, JUDITH · 2013 to 2022
$4.6MMapping spatiotemporal dynamics during enterovirus infection across cells and tissuesR01AI169460 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Raul Andino, Luis J Sigal · 2022 to 2026
$4.5MRECOMBINANT PICORNAVIRUSES AS AIDS VACCINESR01AI036178 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDINO, RAUL · 1994 to 2011
$3.6MDefining the role of Host Hsp70 Subnetworks in Dengue Virus ReplicationR01AI127447 · NIAID · STANFORD UNIVERSITY · PI FRYDMAN, JUDITH · 2017 to 2021
$2.4MGenetic Diversity as a determinant of viral adaptation and pathogenesisR56AI036178 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDINO, RAUL · 2014 to 2014
$531kRECOMBINANT PICORNAVIRUSES AS AIDS VACCINESR21AI036178 · NIAID · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI ANDINO, RAUL · 2000 to 2000
$347kRNA PROTEIN INTERACTIONS IN POLIOVIRUS REPLICATIONR21AI040085 · NIAID · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI ANDINO, RAUL · 1996 to 1996
–NIAID NIH HHS N01 AI040085NIAID NIH HHS P01 AI091575NIAID NIH HHS R01 AI036178NIAID NIH HHS R01 AI127447NIAID NIH HHS R01 AI169460NIAID NIH HHS R21 AI036178NIAID NIH HHS R56 AI036178NIGMS NIH HHS R01 GM056433NIGMS NIH HHS R37 GM056433
Abstract
Viral pathogens are an ongoing threat to public health worldwide. Analysing their dependence on host biosynthetic pathways could lead to effective antiviral therapies
Indexed as
Host-Pathogen InteractionsHydroxylationProtein BiosynthesisCell LineCollagenDengue VirusFlavivirusGene Expression Regulation, ViralGenomicsHost-Derived Cellular FactorsHumansInternal Ribosome Entry SitesMolecular ChaperonesPeptide Chain Initiation, TranslationalPoliovirusPolyribosomesCollagenHost-Derived Cellular FactorsInternal Ribosome Entry SitesMolecular ChaperonesProcollagen-Proline DioxygenaseProlineProtein Aggregates
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.