ArticleNature2021
Dietary fructose improves intestinal cell survival and nutrient absorption.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 2 pooled it
28.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
152 citing papers in PubMed, 2 syntheses or guidelines pooled it, 264 citations in OpenAlex.
- Dietary sugar consumption and health: umbrella review.BMJ (Clinical research ed.) · 2023Pooled it
- Effect of Isomaltulose on Glycemic and Insulinemic Responses: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Shaping the future of early-onset colorectal cancer prevention.Nature reviews. Cancer · 2026Review
- Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026Review
- Dietary Fructose and Early-Onset Colorectal Cancer: Metabolic, Microbial, and Translational Perspectives.Microorganisms · 2026Review
- Intestinal fructose catabolism promotes obesity and insulin resistance via ileal lacteal remodeling.Science advances · 2026Article
- Dietary Regulation of Intestinal Stem Cell Function: Nutrient-Sensing, Microbiota-Mediated, and Regenerative Mechanisms from a Dietetic Perspective.Biomedicines · 2026Review
- Fructose directly remodels the translocase of the outer membrane to impair oxidative phosphorylation in podocytes.Signal transduction and targeted therapy · 2026Article
- Effects of High-Dextrose Intake on the Structural and Functional Properties of the Small Intestine in Young-Maturing and Middle-Aged Rats.International journal of molecular sciences · 2026Article
- Metabolic reprogramming drives pancreatic β cell neogenesis from α cells.Nature chemical biology · 2026Article
- Coffee Pulp and Silverskin Mitigate Fructose-Induced Intestinal Alterations in Rats.Biomolecules · 2026Article
- Gut microbiota promote early-life digestive function in songbirds.bioRxiv : the preprint server for biology · 2026Article
- Reply to Huang et al.: 'Segmental fructose handling may refine the temporal glucagon-like peptide-1/glucagon-like peptide-2 framework during chronic fructose exposure'.The Journal of physiology · 2026Article
- Intestinal fructose metabolism drives unsaturated fat absorption and synergizes with GLP-1 receptor agonism to promote weight loss.bioRxiv : the preprint server for biology · 2026Article
- Fructose 1-phosphate inhibits mannose phosphate isomerase to suppress hepatocellular carcinogenesis.Signal transduction and targeted therapy · 2026Article
- C2orf74 orchestrates germ-Leydig crosstalk to inhibit white adipose tissue browning in male mice.Nature communications · 2026Article
- Sugar reduction in complex food systems: linking metabolic mechanisms, matrix engineering, and safety evaluation.NPJ science of food · 2026Review
- Fructose: metabolic signal and modern hazard.Nature metabolism · 2026Review
- Dietary fiber-driven shifts in mycobiota and short-chain fatty acid landscape in porcine hindgut.Animal microbiome · 2026Article
- Kynurenine promotes porcine intestinal epithelial cell proliferation by activating the AHR-MST1-YAP1 axis.Journal of animal science and biotechnology · 2026Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 1 country.
Samuel R TaylorDivision of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Shakti RamsamoojDivision of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Roger J LiangDivision of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Alyna KattiMeyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Rita PozovskiyDivision of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Neil VasanMeyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Seo-Kyoung HwangDivision of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-0866-5376
Navid NahiyaanDivision of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Nancy J FrancoeurDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Emma M SchatoffDivision of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Jared L JohnsonMeyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-1802-6527
Manish A ShahMeyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Andrew J DannenbergMeyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Robert P SebraDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lukas E DowMeyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-7048-1418
Lewis C CantleyMeyer Cancer Center, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-1298-7653
Kyu Y RheeDivision of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-4582-2895
Marcus D GoncalvesDivision of Endocrinology, Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA. mdg9010@med.cornell.edu.ORCID http://orcid.org/0000-0002-0784-9248
Cornell University · USIcahn School of Medicine at Mount Sinai · USMemorial Sloan Kettering Cancer Center · USSema4 (United States) · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MWeill Cornell/Rockefeller/Sloan-Kettering MST ProgramT32GM007739 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HSU, KATHARINE C · 1985 to 2023
$51.1MRole of Phosphoinositides and Protein Kinases in the control of Cancer MetabolismR35CA197588 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEWIS C. CANTLEY · 2016 to 2026
$10.2MTri-I Training Program in MetabolomicsR25AI140472 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Kyu Y Rhee · 2019 to 2026
$2.4MThe Role of Hypoketonemia in the Cancer Anorexia-Cachexia SyndromeK08CA230318 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GONCALVES, MARCUS DASILVA · 2018 to 2021
$599kSensitizing Colorectal Cancer to Checkpoint Inhibitors by WNT Pathway SuppressionF31CA247351 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI KATTI, ALYNA · 2020 to 2022
$127kNCI NIH HHS F31 CA247351NCI NIH HHS K08 CA230318NCI NIH HHS P30 CA008748NCI NIH HHS R35 CA197588NIAID NIH HHS R25 AI140472NIGMS NIH HHS T32 GM007739
Abstract
Fructose consumption is linked to the rising incidence of obesity and cancer, which are two of the leading causes of morbidity and mortality globally
Indexed as
AnimalsCell SurvivalEnzyme ActivationFemaleFructokinasesFructoseHigh Fructose Corn SyrupHypoxiaIntestinal AbsorptionIntestinal MucosaLipid MetabolismMaleMiceNutrientsPyruvate KinaseFructokinasesFructoseHigh Fructose Corn SyrupketohexokinaseNutrientsPyruvate Kinase
Identifiers
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.