ReviewNature reviews. Genetics2021
Opportunities and challenges of macrogenetic studies.
Review in Nature reviews. Genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- A macrogenetic analysis of isolation mechanisms shaping genetic divergence in mammals.The Journal of heredity · 2026Pooled it
- Spatial Patterns of Intraspecific Genetic Diversity Follow no General Rule Across Climatic and Geographic Gradients.Molecular ecology · 2026Pooled it
- Type Genomics: A Framework for Integrating Genomic Data into Biodiversity and Taxonomic Research.Systematic biology · 2025Guideline
- Pooled it
- Pooled it
- Harnessing macrogenomics to study changing marine ecosystems under global climate change.Proceedings. Biological sciences · 2026Review
- The distribution of fitness effects of nonsynonymous mutations varies phylogenetically across animals.PLoS biology · 2026Article
- Article
- Using herbarium collections to study genetic responses to global change.The New phytologist · 2026Review
- Macrogenetic Alignment in Ecological Strategies Better Interprets Assembly Processes Than Pre-Determined Functional Groupings.Ecology letters · 2026Article
- CartograPlant: bridging genomic, phenotypic, and environmental data to advance plant resilience and eco-evolutionary insight.Genetics · 2026Article
- Navigating Cetacean Mitochondrial Genome Data: Identifying Coverage and Deficiencies in Public Repositories.Molecular ecology resources · 2026Article
- Genetic Diversity Impacts Climate-Induced Species Range Shifts.Ecology letters · 2026Review
- DNA Barcode Reference Library for European Ants: A Roadmap for Phylogeography and Species Discovery.Molecular ecology resources · 2026Article
- Pleistocene demographic histories dominate contemporary genomic diversity in a continental radiation of Himalayan-Hengduan songbirds.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Shared latent genetic liability across fibromyalgia and psychiatric traits: Novel insights from genomic structural equation modeling.PLoS genetics · 2026Article
- Biodiversity conservation requires integration of species-centric and process-based strategies.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Future Projections of Biodiversity Under Global Change Need to Include Genetic Diversity.Global change biology · 2025Article
- In Vouchers We (Hope to) Trust: Unveiling Hidden Errors in GenBank's Tetrapod Taxonomic Foundations.Molecular ecology · 2025Review
- GenDivRange: A global dataset of geo-referenced population genetic diversity across species ranges.Scientific data · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rapidly emerging field of macrogenetics focuses on analysing publicly accessible genetic datasets from thousands of species to explore large-scale patterns and predictors of intraspecific genetic variation. Facilitated by advances in evolutionary biology, technology, data infrastructure, statistics and open science, macrogenetics addresses core evolutionary hypotheses (such as disentangling environmental and life-history effects on genetic variation) with a global focus. Yet, there are important, often overlooked, limitations to this approach and best practices need to be considered and adopted if macrogenetics is to continue its exciting trajectory and reach its full potential in fields such as biodiversity monitoring and conservation. Here, we review the history of this rapidly growing field, highlight knowledge gaps and future directions, and provide guidelines for further research.
Indexed as
Identifiers
34408318What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.