Evidence map›Paper›PMID 34408279›Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022

Foraging with the frontal cortex: A cross-species evaluation of reward-guided behavior.

Peter H Rudebeck, Alicia Izquierdo

Open access · hybridAbstract readReview
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. Rats pursue food and leisure following the same rational principles.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  4. Review
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  8. Review
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  12. Article
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  15. Article
  16. Behaviour, Furnishing and Vertical Space Use of Captive Callimico (Animals : an open access journal from MDPI · 2023
    Article
  17. Article
  18. Article
  19. Subgenual and Hippocampal Pathways in Amygdala Are Set to Balance Affect and Context Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Peter H RudebeckIcahn School of Medicine at Mount Sinai, New York, NY, USA. peter.rudebeck@mssm.edu.ORCID http://orcid.org/0000-0002-1411-7555
Alicia IzquierdoDepartment of Psychology, UCLA, Los Angeles, CA, USA. aizquie@psych.ucla.edu.ORCID http://orcid.org/0000-0001-9897-2091
Icahn School of Medicine at Mount Sinai · USUCLA Health · US

Funding

CRCNS Research Proposal: Cortico-amygdalar substrates of adaptive learningR01DA047870 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alicia Izquierdo, Alireza Soltani · 2018 to 2026
$4.1M
Neural mechanisms of affective processing in prefrontal-limbic circuitsR01MH118638 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI RUDEBECK, PETER · 2019 to 2023
$2.9M
Comparative Neuroanatomy at single-neuron resolutionR34NS122050 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CLEM, ROGER L, RUDEBECK, PETER · 2021 to 2021
$758k
Frontocortical Signaling Signatures in Flexible Reinforcement LearningR21MH122800 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BLAIR, HUGH T, IZQUIERDO, ALICIA · 2021 to 2022
$429k
Modernize animal pharming with emerging gene targeting technologiesR41GM110822 · NIGMS · APPLIED STEMCELL, INC. · PI XU, JIE · 2014 to 2014
$186k
NIDA NIH HHS R01 DA047870NIGMS NIH HHS R41 GM110822NIMH NIH HHS R01 MH118638NIMH NIH HHS R21 MH122800NINDS NIH HHS R34 NS122050
6 · The paper itself

Abstract

Efficient foraging is essential to survival and depends on frontal cortex in mammals. Because of its role in psychiatric disorders, frontal cortex and its contributions to reward procurement have been studied extensively in both rodents and non-human primates. How frontal cortex of these animal models compares is a source of intense debate. Here we argue that translating findings from rodents to non-human primates requires an appreciation of both the niche in which each animal forages as well as the similarities in frontal cortex anatomy and function. Consequently, we highlight similarities and differences in behavior and anatomy, before focusing on points of convergence in how parts of frontal cortex contribute to distinct aspects of foraging in rats and macaques, more specifically. In doing so, our aim is to emphasize where translation of frontal cortex function between species is clearer, where there is divergence, and where future work should focus. We finish by highlighting aspects of foraging for which have received less attention but we believe are critical to uncovering how frontal cortex promotes survival in each species.

Indexed as

Frontal LobeRewardAnimalsAttentionRats

Identifiers

PMID34408279
PMCPMC8617092
OpenAlexW3194919763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.