Evidence map›Paper›PMID 34408276›Full record

ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022

The role of PFC networks in cognitive control and executive function.

Vinod Menon, Mark D'Esposito

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 352 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
352citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

352 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  3. Biopsychosocial and Environmental Factors That Impact Brain-Gut-Microbiome Interactions in Obesity.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026
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  6. Evidence for domain-general arousal from semantic and neuroimaging meta-analyses reconciles opposing views on arousal.Proceedings of the National Academy of Sciences of the United States of America · 2025
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292 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Vinod MenonDepartment of Psychiatry & Behavioral Sciences, Department of Neurology & Neurological Sciences, Stanford Neurosciences Institute, Stanford University, Stanford, CA, USA. menon@stanford.edu.ORCID http://orcid.org/0000-0003-1622-9857
Mark D'EspositoHelen Wills Neuroscience Institute and Department of Psychology, University of California, Berkeley, CA, USA. despo@berkeley.edu.ORCID http://orcid.org/0000-0002-3462-006X

Funding

Working Memory and Prefrontal CortexR01MH063901 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI D'ESPOSITO, MARK · 2001 to 2022
$7.6M
Integrative computational models of latent behavioral and neural constructs in children: a longitudinal developmental big-data approachR01MH121069 · NIMH · STANFORD UNIVERSITY · PI MENON, VINOD · 2019 to 2023
$3.9M
Methods for Dynamic Causal Interactions in Human Brain Function and DysfunctionR01NS086085 · NINDS · STANFORD UNIVERSITY · PI MENON, VINOD · 2014 to 2025
$3.9M
Computational modeling of dynamic causal brain circuits underlying cognitive dysfunction in Alzheimer's diseaseRF1NS086085 · NINDS · STANFORD UNIVERSITY · PI MENON, VINOD · 2021 to 2021
$2.0M
NIMH NIH HHS R01 MH063901NIMH NIH HHS R01 MH121069NINDS NIH HHS R01 NS086085NINDS NIH HHS RF1 NS086085
6 · The paper itself

Abstract

Systems neuroscience approaches with a focus on large-scale brain organization and network analysis are advancing foundational knowledge of how cognitive control processes are implemented in the brain. Over the past decade, technological and computational innovations in the study of brain connectivity have led to advances in our understanding of how brain networks function, inspiring new conceptualizations of the role of prefrontal cortex (PFC) networks in the coordination of cognitive control. In this review, we describe six key PFC networks involved in cognitive control and elucidate key principles relevant for understanding how these networks implement cognitive control. Implementation of cognitive control in a constantly changing environment depends on the dynamic and flexible organization of PFC networks. In this context, we describe major empirical and theoretical models that have emerged in recent years and describe how their functional architecture and dynamic organization supports flexible cognitive control. We take an overarching view of advances made in the past few decades and consider fundamental issues regarding PFC network function, global brain dynamics, and cognition that still need to be resolved. We conclude by clarifying important future directions for research on cognitive control and their implications for advancing our understanding of PFC networks in brain disorders.

Indexed as

Executive FunctionPrefrontal CortexBrainCognition

Identifiers

PMID34408276
PMCPMC8616903

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.