ReviewNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022
The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex.
Review in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
81 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review on resting-state fMRI in people with AUD and people who binge drink.Molecular psychiatry · 2025Pooled it
- Effects of exercise on executive function in individuals with drug addiction: a systematic review and three-level meta-analysis.Frontiers in sports and active living · 2025Pooled it
- The synergy of methylphenidate- and reconsolidation-based extinction normalizes ventromedial prefrontal function in drug addiction.Proceedings of the National Academy of Sciences of the United States of America · 2025Trial
- Repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex in binge eating disorder: a double-blind randomized controlled trial.Psychological medicine · 2025Trial
- Cathodal Transcranial Direct Current Stimulation Does Not Change Implicit Associations Against Alcohol in Alcohol Use Disorder: A Preregistered Clinical Trial.Addiction biology · 2025Trial
- Modulation of Endoplasmic Reticulum Stress via CEBPB: A Potential Molecular Link to Therapeutic Action in Substance Use Disorders.CNS neuroscience & therapeutics · 2026Article
- Heterogeneous structural brain signatures of methamphetamine and ketamine use disorders revealed by normative modeling.Molecular psychiatry · 2026Article
- Beyond Glycemic Control: GLP-1RA-Based Therapies and Emerging Targets Beyond the Metabolic Axis.Journal of clinical medicine · 2026Review
- An emerging role for synaptic ZnPharmacology & therapeutics · 2026Review
- Transcranial direct current stimulation restores addictive behavior via prefrontal-striatal circuit.Molecular psychiatry · 2026Article
- Impairment of the GABAergic system in the prefrontal cortex of male heroin addicts.European archives of psychiatry and clinical neuroscience · 2026Article
- Abnormal DLPFC activation in severe methamphetamine use disorder during abstinence: fNIRS evidence from Stroop task.Frontiers in psychiatry · 2026Article
- Augmenting neurocounseling in addiction recovery with intelligent systems: a roadmap for research and practice.Frontiers in psychiatry · 2026Article
- Non-invasive neurostimulation techniques for the treatment of stimulant use disorders.Frontiers in psychiatry · 2026Review
- Acute aerobic exercise modulates sweetness-related food preference in individuals with nicotine dependence: the mediating role of prefrontal cortical activity.Frontiers in nutrition · 2026Article
- Alpha-2 Adrenergic Agonists Reduce Heavy Alcohol Drinking and Improve Cognitive Performance in Mice.eNeuro · 2026Article
- The Impaired Response Inhibition and Salience Attribution Model of Drug Addiction: Recent Neuroimaging Evidence and Future Directions.Annual review of psychology · 2026Review
- Transcription factors implicated in substance use disorder, from immediate early genes to altered gene expression.Brain research · 2026Review
- Alcohol Cues Elicit Differences in Brain Activation Patterns of Abstinent Men and Women with Alcohol Use Disorders.Neuropsychiatric disease and treatment · 2026Article
- Role of Neuronal Cholecystokinin Receptor: An Emerging Therapeutic Target for Ameliorating Neurological Diseases.Molecular neurobiology · 2025Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A growing preclinical and clinical body of work on the effects of chronic drug use and drug addiction has extended the scope of inquiry from the putative reward-related subcortical mechanisms to higher-order executive functions as regulated by the prefrontal cortex. Here we review the neuroimaging evidence in humans and non-human primates to demonstrate the involvement of the prefrontal cortex in emotional, cognitive, and behavioral alterations in drug addiction, with particular attention to the impaired response inhibition and salience attribution (iRISA) framework. In support of iRISA, functional and structural neuroimaging studies document a role for the prefrontal cortex in assigning excessive salience to drug over non-drug-related processes with concomitant lapses in self-control, and deficits in reward-related decision-making and insight into illness. Importantly, converging insights from human and non-human primate studies suggest a causal relationship between drug addiction and prefrontal insult, indicating that chronic drug use causes the prefrontal cortex damage that underlies iRISA while changes with abstinence and recovery with treatment suggest plasticity of these same brain regions and functions. We further dissect the overlapping and distinct characteristics of drug classes, potential biomarkers that inform vulnerability and resilience, and advancements in cutting-edge psychological and neuromodulatory treatment strategies, providing a comprehensive landscape of the human and non-human primate drug addiction literature as it relates to the prefrontal cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.