Evidence map›Paper›PMID 34408173›Full record

Trial reportScientific reports2021

Association between overall diet quality and postmenopausal breast cancer risk in five Finnish cohort studies.

Satu Männistö, Kennet Harald, Tommi Härkänen, Mirkka Maukonen, Johan G Eriksson, Sanna Heikkinen, Pekka Jousilahti, Niina E Kaartinen, Noora Kanerva, Paul Knekt and 5 more

Open access · goldAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Satu MännistöFinnish Institute for Health and Welfare, PO Box 30, 00271, Helsinki, Finland. satu.mannisto@thl.fi.
Kennet HaraldFinnish Institute for Health and Welfare, PO Box 30, 00271, Helsinki, Finland.
Tommi HärkänenFinnish Institute for Health and Welfare, PO Box 30, 00271, Helsinki, Finland.
Mirkka MaukonenFinnish Institute for Health and Welfare, PO Box 30, 00271, Helsinki, Finland.
Johan G ErikssonFinnish Institute for Health and Welfare, PO Box 30, 00271, Helsinki, Finland.
Sanna HeikkinenFinnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
Pekka JousilahtiFinnish Institute for Health and Welfare, PO Box 30, 00271, Helsinki, Finland.
Niina E KaartinenFinnish Institute for Health and Welfare, PO Box 30, 00271, Helsinki, Finland.
Noora KanervaDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Paul KnektFinnish Institute for Health and Welfare, PO Box 30, 00271, Helsinki, Finland.
Seppo KoskinenFinnish Institute for Health and Welfare, PO Box 30, 00271, Helsinki, Finland.
Maarit A LaaksonenFinnish Institute for Health and Welfare, PO Box 30, 00271, Helsinki, Finland.
Nea MalilaFinnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
Harri RissanenFinnish Institute for Health and Welfare, PO Box 30, 00271, Helsinki, Finland.
Janne PitkäniemiFinnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland.
Finnish Institute for Health and Welfare · FIFinnish Cancer Registry · FIUniversity of Helsinki · FINational University of Singapore · SG

Funding

NCI CLINICAL INVESTIGATOR AWARD PROGRAMK08CA001022 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BUBLEY, GLENN J · 1987 to 1989
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6 · The paper itself

Abstract

There is limited evidence for any dietary factor, except alcohol, in breast cancer (BC) risk. Therefore, studies on a whole diet, using diet quality indices, can broaden our insight. We examined associations of the Nordic Diet (mNDI), Mediterranean diet (mMEDI) and Alternative Healthy Eating Index (mAHEI) with postmenopausal BC risk. Five Finnish cohorts were combined including 6374 postmenopausal women with dietary information. In all, 8-9 dietary components were aggregated in each index, higher total score indicating higher adherence to a healthy diet. Cox proportional hazards regression was used to estimate the combined hazard ratio (HR) and 95% confidence interval (CI) for BC risk. During an average 10-year follow-up period, 274 incident postmenopausal BC cases were diagnosed. In multivariable models, the HR for highest vs. lowest quintile of index was 0.67 (95 %CI 0.48-1.01) for mNDI, 0.88 (0.59-1.30) for mMEDI and 0.89 (0.60-1.32) for mAHEI. In this combined dataset, a borderline preventive finding of high adherence to mNDI on postmenopausal BC risk was found. Of the indices, mNDI was more based on the local food culture than the others. Although a healthy diet has beneficially been related to several chronic diseases, the link with the etiology of postmenopausal BC does not seem to be that obvious.

Indexed as

Diet, HealthyDiet, MediterraneanPostmenopauseAgedBreast NeoplasmsFemaleFinlandFollow-Up StudiesHumansMiddle AgedProportional Hazards ModelsRisk Factors

Identifiers

PMID34408173
PMCPMC8373908
OpenAlexW3195194585

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.