ArticleScience translational medicine2021
Blocking α
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Vedolizumab and ART in recent HIV-1 infection unveil the role of α4β7 in reservoir size.JCI insight · 2024Trial
- HIV-1 bNAb Vaccinal Effect-An Underachieving Goal?Current HIV research · 2026Review
- IL-21 and anti-α4β7 dual therapy during ART promotes immunological and microbiome responses in SIV-infected macaques.JCI insight · 2025Article
- Exploring HIV Vaccine Progress in the Pre-Clinical and Clinical Setting: From History to Future Prospects.Viruses · 2024Review
- TGF-β blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo.Nature communications · 2024Article
- MAdCAM-1 costimulation in the presence of retinoic acid and TGF-β promotes HIV infection and differentiation of CD4+ T cells into CCR5+ TRM-like cells.PLoS pathogens · 2023Article
- Host Molecule Incorporation into HIV Virions, Potential Influences in HIV Pathogenesis.Viruses · 2022Review
- Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo.JCI insight · 2022Article
- Review
- Early treatment with anti-αFrontiers in immunology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 7 institutions in 1 country.
Ines FrankCenter for Biomedical Research, Population Council, New York, NY, USA.ORCID 0000-0001-9345-9942
Mariasole CigoliCenter for Biomedical Research, Population Council, New York, NY, USA.ORCID 0000-0001-9766-5276
Muhammad S ArifDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-7129-3312
Marissa D FahlbergTulane National Primate Research Center, Tulane University, Covington, LA, USA.ORCID 0000-0002-2597-7147
Stephanie MaldonadoCenter for Biomedical Research, Population Council, New York, NY, USA.
Giulia CalendaCenter for Biomedical Research, Population Council, New York, NY, USA.
Amarendra PeguVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.ORCID 0000-0003-3564-6453
Eun Sung YangVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.ORCID 0000-0003-3161-1624
Reda RawiVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Gwo-Yu ChuangVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Hui GengVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.ORCID 0000-0002-7389-6931
Cuiping LiuVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Tongqing ZhouVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.ORCID 0000-0002-3935-4637
Peter D KwongVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.ORCID 0000-0003-3560-232X
James ArthosLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-6767-4267
Claudia CicalaLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-1181-8997
Brooke F GraspergeTulane National Primate Research Center, Tulane University, Covington, LA, USA.ORCID 0000-0002-1262-6217
James L BlanchardTulane National Primate Research Center, Tulane University, Covington, LA, USA.ORCID 0000-0001-9855-7728
Agegnehu GettieAaron Diamond AIDS Research Center, Rockefeller University, New York, NY, USA.
Christine M FennesseyAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID 0000-0002-8736-8523
Brandon F KeeleAIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID 0000-0002-2381-1151
Monica VaccariTulane National Primate Research Center, Tulane University, Covington, LA, USA.ORCID 0000-0002-4514-2681
Thomas J HopeDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-7183-8319
Anthony S FauciLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-7865-7235
John R MascolaVaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.ORCID 0000-0002-5293-4695
Elena MartinelliCenter for Biomedical Research, Population Council, New York, NY, USA. elena.martinelli@northwestern.edu.ORCID 0000-0002-3416-9627
National Institute of Allergy and Infectious Diseases · USPopulation Council · USTulane University · USNational Institutes of Health · USNorthwestern University · USFrederick National Laboratory for Cancer Research · USAaron Diamond AIDS Research Center · US
Funding
WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6MTulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4MViral Testing CoreU42OD024282 · OD · TULANE UNIVERSITY OF LOUISIANA · PI KASI E RUSSELL-LODRIGUE · 2017 to 2026
$25.7MNeutralization Mechanisms Of Anti-HIV-1 Monoclonal AntibodiesZIAAI005022 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ZHOU, TONGQING · 2009 to 2025
$24.6MViral Testing Core - Maintenance of an SPF Macaque Breeding Colony for AIDS ResearchU42OD010568 · OD · TULANE UNIVERSITY OF LOUISIANA · PI KASI E RUSSELL-LODRIGUE · 2013 to 2026
$21.7MNonhuman Primate Reagent ResourceU24AI126683 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2016 to 2026
$20.1MHIV/AIDS Vaccine and Antibody DevelopmentZICAI005002 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHENG, CHENG · 2019 to 2025
$17.6MIdentification of the Initial Targets of Transmission R37AI094595 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Thomas Hope · 2017 to 2026
$10.0MResource CoreP40OD028116 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2020 to 2026
$5.9MDesign of Antigenically-Specific Probes for Sera Analysis and MAb IsolationZICAI005111 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI ZHOU, TONGQING · 2010 to 2025
$4.3MRole of integrins in HIV/SIV transmission across cervico-vaginal mucosaR01AI098546 · NIAID · POPULATION COUNCIL · PI MARTINELLI, ELENA · 2012 to 2016
$3.9MCCR NIH HHS HHSN261200800001CNCI NIH HHS 75N91019D00024NCI NIH HHS HHSN261200800001ENIAID NIH HHS R01 AI098546NIAID NIH HHS R37 AI094595NIAID NIH HHS U24 AI126683NIH HHS P40 OD028116NIH HHS P51 OD011104NIH HHS U42 OD010568NIH HHS U42 OD024282
Abstract
Anti-HIV broadly neutralizing antibodies (bNAbs) may favor development of antiviral immunity by engaging the immune system during immunotherapy. Targeting integrin α
Indexed as
HIV-1HIV InfectionsSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAnimalsAntibodies, NeutralizingAntibodies, ViralBroadly Neutralizing AntibodiesHIV AntibodiesIntegrinsMacaca mulattaAntibodies, NeutralizingAntibodies, ViralBroadly Neutralizing AntibodiesHIV Antibodiesintegrin alpha4beta7Integrins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.