ArticleBMJ (Clinical research ed.)2021
Associations of BNT162b2 vaccination with SARS-CoV-2 infection and hospital admission and death with covid-19 in nursing homes and healthcare workers in Catalonia: prospective cohort study.
Article in BMJ (Clinical research ed.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 3 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 3 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Effective infection prevention and control measures in long-term care facilities in non-outbreak and outbreak settings: a systematic literature review.Antimicrobial resistance and infection control · 2023Pooled it
- The effectiveness of COVID-19 vaccines in reducing the incidence, hospitalization, and mortality from COVID-19: A systematic review and meta-analysis.Frontiers in public health · 2022Pooled it
- Real-world effectiveness of BNT162b2 mRNA vaccine: a meta-analysis of large observational studies.Inflammopharmacology · 2021Pooled it
- Observational methods for COVID-19 vaccine effectiveness research: an empirical evaluation and target trial emulation.International journal of epidemiology · 2024Trial
- Extensive cross-reactive T cell epitopes across SARS-CoV-2 Omicron variant spikes with finite immune evasion mutations.Journal of translational medicine · 2025Article
- Impact of ceiling of care on mortality across four COVID-19 epidemic waves in Catalonia: a multicentre prospective cohort study.BMJ open · 2025Article
- Effectiveness of nirsevimab immunoprophylaxis against respiratory syncytial virus-related outcomes in hospital and primary care settings: a retrospective cohort study in infants in Catalonia (Spain).Archives of disease in childhood · 2024Article
- Impact of SARS-CoV-2 vaccines on Covid-19 incidence and mortality in the United States.PloS one · 2024Article
- The disparity in hesitancy toward COVID-19 vaccination between older individuals in nursing homes and those in the community in Taizhou, China.BMC geriatrics · 2023Article
- An analysis of the waning effect of COVID-19 vaccinations.Genomics & informatics · 2023Article
- Risk Factors for Long COVID in Older Adults.Biomedicines · 2023Review
- Partisan self-identification predicts attitudes of South Dakota nurses toward COVID-19 vaccine mandate for healthcare workers.Health policy and technology · 2023Article
- Impact of prior SARS-COV-2 infection and vaccination on COVID-19 hospital admission and mortality amongst nursing home residents.Aging clinical and experimental research · 2023Article
- Evidence for positive long- and short-term effects of vaccinations against COVID-19 in wearable sensor metrics.PNAS nexus · 2023Article
- Vaccination and COVID-19 positivity rates in a network of eye hospitals in Southern and Eastern India during the second wave of COVID-19.Indian journal of ophthalmology · 2023Article
- Understanding the challenges to COVID-19 vaccines and treatment options, herd immunity and probability of reinfection.Journal of Taibah University Medical Sciences · 2023Review
- Immunovirological and environmental screening reveals actionable risk factors for fatal COVID-19 during post-vaccination nursing home outbreaks.Nature aging · 2023Article
- Development of a COVID-19 vaccine effectiveness and safety assessment system in Japan: The VENUS study.Vaccine · 2023Article
- Article
- Higher plasma levels of thymosin-α1 are associated with a lower waning of humoral response after COVID-19 vaccination: an eight months follow-up study in a nursing home.Immunity & ageing : I & A · 2023Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine associations of BNT162b2 vaccination with SARS-CoV-2 infection and hospital admission and death with covid-19 among nursing home residents, nursing home staff, and healthcare workers.
designProspective cohort study.
settingNursing homes and linked electronic medical record, test, and mortality data in Catalonia on 27 December 2020.
participants28 456 nursing home residents, 26 170 nursing home staff, and 61 791 healthcare workers.
main outcome measuresParticipants were followed until the earliest outcome (confirmed SARS-CoV-2 infection, hospital admission or death with covid-19) or 26 May 2021. Vaccination status was introduced as a time varying exposure, with a 14 day run-in after the first dose. Mixed effects Cox models were fitted to estimate hazard ratios with index month as a fixed effect and adjusted for confounders including sociodemographics, comorbidity, and previous medicine use.
resultsAmong the nursing home residents, SARS-CoV-2 infection was found in 2482, 411 were admitted to hospital with covid-19, and 450 died with covid-19 during the study period. In parallel, 1828 nursing home staff and 2968 healthcare workers were found to have SARS-CoV-2 infection, but fewer than five were admitted or died with covid-19. The adjusted hazard ratio for SARS-CoV-2 infection after two doses of vaccine was 0.09 (95% confidence interval 0.08 to 0.11) for nursing home residents, 0.20 (0.17 to 0.24) for nursing home staff, and 0.13 (0.11 to 0.16) for healthcare workers. Adjusted hazard ratios for hospital admission and mortality after two doses of vaccine were 0.05 (0.04 to 0.07) and 0.03 (0.02 to 0.04), respectively, for nursing home residents. Nursing home staff and healthcare workers recorded insufficient events for mortality analysis.
conclusionsVaccination was associated with 80-91% reduction in SARS-CoV-2 infection in all three cohorts and greater reductions in hospital admissions and mortality among nursing home residents for up to five months. More data are needed on longer term effects of covid-19 vaccines.
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