Evidence map›Paper›PMID 34407873›Full record

ArticleCell & bioscience2021

JAZF1 heterozygous knockout mice show altered adipose development and metabolism.

Jain Jeong, Soyoung Jang, Song Park, Wookbong Kwon, Si-Yong Kim, Soyoen Jang, Jiwon Ko, Si Jun Park, Su-Geun Lim, Duhak Yoon and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Jain Jeong *Digestive Diseases Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Soyoung Jang *School of Life Sciences, BK21 FOUR KNU Creative BioResearch, Kyungpook National University, Daegu, 41566, Republic of Korea.
Song Park *Core Protein Resources Center, DGIST, Daegu, 42988, Republic of Korea.
Wookbong KwonDivision of Biotechnology, DGIST, Daegu, Republic of Korea.
Si-Yong KimSchool of Life Sciences, BK21 FOUR KNU Creative BioResearch, Kyungpook National University, Daegu, 41566, Republic of Korea.
Soyoen JangSchool of Life Sciences, BK21 FOUR KNU Creative BioResearch, Kyungpook National University, Daegu, 41566, Republic of Korea.
Jiwon KoSchool of Life Sciences, BK21 FOUR KNU Creative BioResearch, Kyungpook National University, Daegu, 41566, Republic of Korea.
Si Jun ParkSchool of Life Sciences, BK21 FOUR KNU Creative BioResearch, Kyungpook National University, Daegu, 41566, Republic of Korea.
Su-Geun LimSchool of Life Sciences, BK21 FOUR KNU Creative BioResearch, Kyungpook National University, Daegu, 41566, Republic of Korea.
Duhak YoonDepartment of Animal Science, Kyungpook National University, Daegu, 37224, Republic of Korea.
Junkoo YiGyeongsangbukdo Livestock Research Institute, Yeongju, Republic of Korea.
Sanggyu LeeSchool of Life Sciences, BK21 FOUR KNU Creative BioResearch, Kyungpook National University, Daegu, 41566, Republic of Korea.
Myoung Ok KimSchool of Animal Science and Biotechnology, Kyungpook National University, Daegu, Korea.
Seong-Kyoon Choi *Core Protein Resources Center, DGIST, Daegu, 42988, Republic of Korea. cskbest@dgist.ac.kr.
Zae Young Ryoo *School of Life Sciences, BK21 FOUR KNU Creative BioResearch, Kyungpook National University, Daegu, 41566, Republic of Korea. jaewoong64@knu.ac.kr.ORCID http://orcid.org/0000-0001-6993-3624
Kyungpook National University · KRDaegu Gyeongbuk Institute of Science and Technology · KRGyeongsangnam-do Agricultural Research and Extension Services · KRYale University · US

Funding

Daegu Gyeongbuk Institute of Science and Technology 2020010096National Research Foundation of Korea 2020R1A4A1018280National Research Foundation of Korea 2020R1I1A1A01074542National Research Foundation of Korea 2020R1I1A2075315National Research Foundation of Korea NRF-2021R1F1A1045382
6 · The paper itself

Abstract

backgroundJuxtaposed with another zinc finger protein 1 (JAZF1) is associated with metabolic disorders, including type 2 diabetes mellitus (T2DM). Several studies showed that JAZF1 and body fat mass are closely related. We attempted to elucidate the JAZF1 functions on adipose development and related metabolism using in vitro and in vivo models.

resultsThe JAZF1 expression was precisely regulated during adipocyte differentiation of 3T3-L1 preadipocyte and mouse embryonic fibroblasts (MEFs). Homozygous JAZF1 deletion (JAZF1-KO) resulted in impaired adipocyte differentiation in MEF. The JAZF1 role in adipocyte differentiation was demonstrated by the regulation of PPARγ-a key regulator of adipocyte differentiation. Heterozygous JAZF1 deletion (JAZF1-Het) mice fed a normal diet (ND) or a high-fat diet (HFD) had less adipose tissue mass and impaired glucose homeostasis than the control (JAZF1-Cont) mice. However, other metabolic organs, such as brown adipose tissue and liver, were negligible effect on JAZF1 deficiency.

conclusionOur findings emphasized the JAZF1 role in adipocyte differentiation and related metabolism through the heterozygous knockout mice. This study provides new insights into the JAZF1 function in adipose development and metabolism, informing strategies for treating obesity and related metabolic disorders.

Indexed as

Adipocyte differentiationAdipogenesisGlucose homeostasisInsulin resistanceJAZF1PPARγ

Identifiers

PMID34407873
PMCPMC8375039
OpenAlexW3194148256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.