ArticleStem cell research & therapy2021
Bone marrow mesenchymal stem cells derived from juvenile macaques reversed ovarian ageing in elderly macaques.
Article in Stem cell research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- A study on 18F-FDG PET/CT imaging assessment of the anti-aging efficacy of BMMSCs in the macaque brain.Stem cells translational medicine · 2026Article
- Decoding the genetic architecture of women reproductive aging: multi-omic integration identifies novel loci and mechanistic pathways for precision intervention.BMC genomics · 2025Article
- Precision medicine in premature ovarian insufficiency: a focus on the precision therapeutic strategies for mesenchymal stem cells.Stem cell research & therapy · 2025Review
- Mesenchymal stem cells reverse thymus aging by reprogramming the DNA methylation of thymic epithelial cells.Regenerative therapy · 2024Article
- Review
- Stem cell transplantation extends the reproductive life span of naturally aging cynomolgus monkeys.Cell discovery · 2024Article
- Use of mesenchymal stem cells to enhance or restore fertility potential: a systematic review of available experimental strategies.Human reproduction open · 2023Review
- Mesenchymal stem cells to treat female infertility; future perspective and challenges: A review.International journal of reproductive biomedicine · 2022Review
- Aged mice ovaries harbor stem cells and germ cell nests but fail to form follicles.Journal of ovarian research · 2022Article
- Aging conundrum: A perspective for ovarian aging.Frontiers in endocrinology · 2022Review
- Cell-Free Fat Extract Improves Ovarian Function and Fertility in Mice With Advanced Age.Frontiers in endocrinology · 2022Article
- Very small embryonic-like stem cells have the potential to win the three-front war on tissue damage, cancer, and aging.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFemale sex hormone secretion and reproductive ability decrease with ageing. Bone marrow mesenchymal stem cells (BMMSCs) have been postulated to play a key role in treating ovarian ageing.
methodsWe used macaque ovarian ageing models to observe the structural and functional changes after juvenile BMMSC treatment. Moreover, RNA-seq was used to analyse the ovarian transcriptional expression profile and key pathways through which BMMSCs reverse ovarian ageing.
resultsIn the elderly macaque models, the ovaries were atrophied, the regulation ability of sex hormones was reduced, the ovarian structure was destroyed, and only local atretic follicles were observed, in contrast with young rhesus monkeys. Intravenous infusion of BMMSCs in elderly macaques increased ovarian volume, strengthened the regulation ability of sex hormones, reduced the degree of pulmonary fibrosis, inhibited apoptosis, increased density of blood vessels, and promoted follicular regeneration. In addition, the ovarian expression characteristics of ageing-related genes of the elderly treatment group reverted to that of the young control group, 1258 genes that were differentially expressed, among which 415 genes upregulated with age were downregulated, 843 genes downregulated with age were upregulated after BMMSC treatment, and the top 20 differentially expressed genes (DEGs) in the protein-protein interaction (PPI) network were significantly enriched in oocyte meiosis and progesterone-mediated oocyte maturation pathways.
conclusionThe BMMSCs derived from juvenile macaques can reverse ovarian ageing in elderly macaques.
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Registered trials
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