Evidence map›Paper›PMID 34407777›Full record

ArticleBMC musculoskeletal disorders2021

Material properties of human vertebral trabecular bone under compression can be predicted based on quantitative computed tomography.

Dominic Gehweiler, Marius Schultz, Martin Schulze, Oliver Riesenbeck, Dirk Wähnert, Michael J Raschke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Dominic GehweilerAO Research Institute Davos, Clavadelerstrasse 8, 7270, Davos, Switzerland.
Marius SchultzUniversity Hospital Muenster, Department of Trauma, Hand and Reconstructive Surgery, Albert-Schweitzer-Campus 1, Building W1, 48149, Muenster, Germany.
Martin SchulzeDepartment of Orthopedics, University Hospital Muenster, Albert-Schweitzer-Campus 1, 48149, Muenster, Germany.
Oliver RiesenbeckUniversity Hospital Muenster, Department of Trauma, Hand and Reconstructive Surgery, Albert-Schweitzer-Campus 1, Building W1, 48149, Muenster, Germany.
Dirk Wähnert *University Hospital Muenster, Department of Trauma, Hand and Reconstructive Surgery, Albert-Schweitzer-Campus 1, Building W1, 48149, Muenster, Germany. Dirk.Waehnert@evkb.de.
Michael J Raschke *University Hospital Muenster, Department of Trauma, Hand and Reconstructive Surgery, Albert-Schweitzer-Campus 1, Building W1, 48149, Muenster, Germany.
University Hospital Münster · DEAO Foundation · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe prediction of the stability of bones is becoming increasingly important. Especially osteoporotic vertebral body fractures are a growing problem and an increasing burden on the health system. Therefore, the aim of this study was to provide the best possible description of the relationship between the material properties of human vertebral trabecular bone measured under the most physiological conditions possible and the bone mineral density (BMD) determined by clinical quantitative computed tomography (QCT).

methodsForty eight cylindric cancellous bone samples with a diameter of 7.2 mm obtained from 13 human fresh-frozen lumbar vertebrae from 5 donors (3 men, 2 women) have been used for this study. After the specimens were temporarily reinserted into the vertebral body, the QCT was performed. For mechanical testing, the samples were embedded in a load-free manner using polymethylmetacrylate (PMMA). The surrounding test chamber was filled with phosphate buffered saline (PBS) and heated to 37 °C during the test. After 10 preconditioning load cycles, destructive testing was performed under axial compression. After determining the fracture site, BMD has been evaluated in this region only. Regression analyses have been performed.

resultsFracture site had an average length of 2.4 (±1.4) mm and a position of 43.9 (±10.9) percent of the measurement length from the cranial end. No fracture reached the embedding. The average BMD at the fracture site was 80.2 (±28.7 | min. 14.5 | max. 137.8) mgCaHA/ml. In summary the results of the regression analyses showed for all three parameters a very good quality of fit by a power regression.

conclusionThe results of this study show that QCT-based bone density measurements have a good predictive power for the material properties of the vertebral cancellous bone measured under near to physiological conditions. The mechanical bone properties of vertebral cancellous bone could be modelled with high accuracy in the investigated bone density range.

Indexed as

Osteoporotic FracturesSpinal FracturesBone DensityCancellous BoneFemaleHumansLumbar VertebraeMaleTomography, X-Ray ComputedBiomechanicsCancellous boneHuman vertebraMaterial properties

Identifiers

PMID34407777
PMCPMC8375123
OpenAlexW3196260343

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.