Evidence map›Paper›PMID 34407771›Full record

Trial reportBMC pregnancy and childbirth2021

Changing knowledge, attitudes and behaviours towards cytomegalovirus in pregnancy through film-based antenatal education: a feasibility randomised controlled trial of a digital educational intervention.

Anna Calvert, Tushna Vandrevala, Robin Parsons, Victoria Barber, Alex Book, Gayle Book, David Carrington, Vanessa Greening, Paul Griffiths, Danielle Hake and 8 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pregnancy and childbirth, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03511274 (Reducing Acquisition of CMV Through Antenatal Education), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03511274 nacompletednot on this map

Reducing Acquisition of CMV Through Antenatal Education: A Feasibility Study to Assess an Educational Intervention to Prevent Cytomegalovirus Infection in Pregnancy

TypeinterventionalSponsorSt George's, University of LondonRan2017 to 2020Enrolled878ConditionsCytomegalovirus CongenitalArmsHygiene based educational film
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  13. Observational
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  15. Cytomegalovirus and Pregnancy: A Narrative Review.Journal of clinical medicine · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 1 country.

Anna CalvertPaediatric Infectious Diseases Research Group, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK. acalvert@sgul.ac.uk.
Tushna VandrevalaDepartment of Psychology, Kingston University, Kingston-Upon-Thames, UK.
Robin ParsonsPaediatric Infectious Diseases Research Group, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.
Victoria BarberDepartment of Psychology, Kingston University, Kingston-Upon-Thames, UK.
Alex BookParent Caring for a Child With Congenital CMV Infection, London, UK.
Gayle BookParent Caring for a Child With Congenital CMV Infection, London, UK.
David CarringtonSt George's University Hospitals NHS Foundation Trust, London, UK.
Vanessa GreeningPaediatric Infectious Diseases Research Group, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.
Paul GriffithsUniversity College London, Medical School, Institute of Immunity and Transplantation, London, UK.
Danielle HakePaediatric Infectious Diseases Research Group, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.
Asma KhalilPaediatric Infectious Diseases Research Group, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.
Suzanne LuckPaediatric Infectious Diseases Research Group, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.
Amy MontagueDepartment of Psychology, Kingston University, Kingston-Upon-Thames, UK.
Caroline StarCMV Action, London, UK.
Irina Chis SterInstitute of Infection and Immunity, St George's University of London, London, UK.
Sharon WoodCMV Action, London, UK.
Paul T HeathPaediatric Infectious Diseases Research Group, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.
Christine E JonesPaediatric Infectious Diseases Research Group, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.
St George’s University Hospitals NHS Foundation Trust · GBKingston University · GBAction for ME · GBSt George's, University of London · GBKingston Hospital · GBUniversity College London · GBUniversity of Southampton · GB

Funding

Research for Patient Benefit Programme PB-PG-0215-36120
6 · The paper itself

Abstract

backgroundCongenital cytomegalovirus (CMV) is the most common congenital infection globally, however information about CMV is not routinely included in antenatal education in the United Kingdom. This feasibility study aimed to gather the essential data needed to design and power a large randomised controlled trial (RCT) to investigate the efficacy of a digital intervention in reducing the risk of CMV acquisition in pregnancy. In order to do this, we carried out a single-centre RCT, which explored the knowledge, attitudes and risk reduction behaviours in women in the intervention and treatment as usual groups, pre- and post-intervention.

methodsCMV seronegative women living with a child less than four years old, receiving antenatal care at a single UK tertiary centre, were randomised to the digital intervention or 'treatment as usual' groups. Participants completed questionnaires before the digital intervention and after and at 34 gestational weeks, and responses within groups and between groups were compared using tailored randomisation tests. CMV serology was tested in the first trimester and at the end of pregnancy.

resultsOf the 878 women screened, 865 samples were analysed with 43% (n = 372) being CMV seronegative and therefore eligible to take part in the RCT; of these, 103 (27.7%) women were enrolled and 87 (84%) of these completed the study. Most participants (n = 66; 64%) were unfamiliar with CMV at enrolment, however at 34 gestational weeks, women in the intervention group (n = 51) were more knowledgeable about CMV compared to the treatment as usual group (n = 52) and reported engaging in activities that may increase the risk of CMV transmission less frequently. The digital intervention was highly acceptable to pregnant women. Overall, four participants seroconverted over the course of the study: two from each study group.

conclusionsA large multi-centre RCT investigating the efficacy of a CMV digital intervention is feasible in the United Kingdom; this study has generated essential data upon which to power such a study. This single-centre feasibility RCT demonstrates that a digital educational intervention is associated with increase in knowledge about CMV and can result in behaviour change which may reduce the risk of CMV acquisition in pregnancy.

trial registrationClinicaltrials.gov, NCT03511274 , Registered 27.04.18, http://www.Clinicaltrials.gov.

Indexed as

Health Knowledge, Attitudes, PracticeAdultCytomegalovirusCytomegalovirus InfectionsFeasibility StudiesFemaleHumansMiddle AgedMotion PicturesPregnancyPrenatal CarePrenatal EducationRisk FactorsRisk-TakingUnited KingdomAntenatal educationCongenital infectionCytomegalovirusFeasibilityPregnancy

Identifiers

PMID34407771
PMCPMC8375137
OpenAlexW3180877766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.