Evidence map›Paper›PMID 34407766›Full record

ArticleBasic and clinical andrology2021

Will whole-genome sequencing become the first-line genetic analysis for male infertility in the near future?

Farah Ghieh, Anne-Laure Barbotin, Clara Leroy, François Marcelli, Nelly Swierkowsky-Blanchard, Valérie Serazin, Béatrice Mandon-Pepin, François Vialard

Abstract readEditorial
In one paragraph

Article in Basic and clinical andrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Farah GhiehUVSQ, INRAE, BREED, Université Paris-Saclay, F-78350, Jouy-en-Josas, France.
Anne-Laure BarbotinInstitut de Biologie de la Reproduction-Spermiologie-CECOS, Hôpital Jeanne de Flandre, Centre Hospitalier et Universitaire, F -59000, Lille, France.
Clara LeroyInstitut de Biologie de la Reproduction-Spermiologie-CECOS, Hôpital Jeanne de Flandre, Centre Hospitalier et Universitaire, F -59000, Lille, France.
François MarcelliInstitut de Biologie de la Reproduction-Spermiologie-CECOS, Hôpital Jeanne de Flandre, Centre Hospitalier et Universitaire, F -59000, Lille, France.
Nelly Swierkowsky-BlanchardUVSQ, INRAE, BREED, Université Paris-Saclay, F-78350, Jouy-en-Josas, France.
Valérie SerazinUVSQ, INRAE, BREED, Université Paris-Saclay, F-78350, Jouy-en-Josas, France.
Béatrice Mandon-PepinUVSQ, INRAE, BREED, Université Paris-Saclay, F-78350, Jouy-en-Josas, France.
François VialardUVSQ, INRAE, BREED, Université Paris-Saclay, F-78350, Jouy-en-Josas, France. francois.vialard@uvsq.fr.ORCID http://orcid.org/0000-0002-5774-2756

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whereas the initially strategy for the genetic analysis of male infertility was based on a candidate gene approach, the development of next-generation sequencing technologies (such as whole-exome sequencing (WES)) provides an opportunity to analyze many genes in a single procedure. In order to recommend WES or whole-genome sequencing (WGS) after genetic counselling, an objective evaluation of the current genetic screening strategy for male infertility is required, even if, at present, we have to take into consideration the complexity of such a procedure, not discussed in this commentary.

Indexed as

AzoospermiaGlobozoospermiaMacrozoospermiaMale infertilityMultiple morphological abnormalities of the flagellaWhole-genome sequencing

Identifiers

PMID34407766
PMCPMC8375164

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.