Evidence map›Paper›PMID 34407758›Full record

ArticleBMC neurology2021

Guillain-Barré syndrome as the first presentation of human immunodeficiency virus infection.

Mariana Lopes, Patrícia Marques, Bruno Silva, Gonçalo Cruz, José Eduardo Serra, Eugenia Ferreira, Helena Alves, José Saraiva da Cunha

Abstract readCase Reports
In one paragraph

Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mariana Lopes *Department of Infectious Diseases, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal. m.cardosolopes92@gmail.com.ORCID http://orcid.org/0000-0002-4181-0830
Patrícia Marques *Department of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Bruno SilvaDepartment of Neurology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Gonçalo CruzDepartment of Infectious Diseases, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
José Eduardo SerraDepartment of Infectious Diseases, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Eugenia FerreiraDepartment of Infectious Diseases, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Helena AlvesDepartment of Infectious Diseases, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
José Saraiva da CunhaDepartment of Infectious Diseases, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimAntiretroviral therapy (ART) development has reduced the severity of neurological complications of the human immunodeficiency virus (HIV), but they remain prevalent and need prompt recognition. Acute inflammatory demyelinating polyneuropathy (AIDP) is a rare complication of human immunodeficiency virus (HIV) infection that may appear at any stage of the disease. In this case, AIDP represents a late presentation of HIV infection.

methodsDescriptive study. Patient data were collected from their medical records and by health assessment interviews.

resultsWe report a case of a 52-year-old male with acute lower limb weakness. Given the suggestive clinical presentation of AIDP and a positive HIV test, intravenous immunoglobulin (IVIG) was administered along with antiretroviral therapy. Progressive weakness to the upper limbs, autonomic dysfunction, and pain was observed. The second regimen of IVIG plus corticosteroids was administered. Muscle strength improved after three weeks.

conclusionsScreening for HIV in a patient with AIDP may provide a better outcome because of the early start of ART with good central nervous system penetration in HIV-infected patients.

Indexed as

Antiretroviral Therapy, Highly ActivePrimary DysautonomiasAdrenal Cortex HormonesGuillain-Barre SyndromeHIV InfectionsHumansImmunoglobulins, IntravenousMaleMiddle AgedMuscle WeaknessTreatment OutcomeAdrenal Cortex HormonesImmunoglobulins, IntravenousAntiretroviral TherapyGuillain-Barre SyndromeHIV

Identifiers

PMID34407758
PMCPMC8371896

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.