Evidence map›Paper›PMID 34407676›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2021

Progression of central nervous system disease from pediatric to young adulthood in sickle cell anemia.

Grace Champlin, Scott N Hwang, Andrew Heitzer, Juan Ding, Lisa Jacola, Jeremie H Estepp, Winfred Wang, Kenneth I Ataga, Curtis L Owens, Justin Newman and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Grace ChamplinDepartment of Clinical Education and Training, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Scott N HwangDepartment of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Andrew HeitzerDepartment of Psychology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Juan DingDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Lisa JacolaDepartment of Psychology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jeremie H EsteppDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Winfred WangDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kenneth I AtagaUniversity of Tennessee Health Science Center (UTHSC), Center for Sickle Cell Disease, Memphis, TN 38163, USA.
Curtis L OwensMethodist University Comprehensive Sickle Cell Center, Memphis, TN 38104, USA.
Justin NewmanMemphis Radiological Professional Corporation, Memphis, TN 38138, USA.
Allison A KingWashington University School of Medicine, St. Louis, MO 63130, USA.
Robert DavisCenter in Biomedical Informatics at UTHSC, Memphis, TN 38163, USA.
Guolian KangDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Jane S HankinsDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0003-4439-7321
St. Jude Children's Research Hospital · USUniversity of Tennessee Health Science Center · USMethodist University · USWashington University in St. Louis · US

Funding

The Implementation of Cognitive Screening and Educational Support to Improve Outcomes of Adolescents and Young Adults with Sickle Cell Disease: From Clinic to the Community and BackU01HL133994 · NHLBI · WASHINGTON UNIVERSITY · PI KING, ALLISON A · 2016 to 2021
$5.2M
RE-aiming at Hydroxyurea Adherence for Sickle cell with mHealth (RE-HASH)U01HL133996 · NHLBI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HANKINS, JANE SILVA, KLESGES, LISA M · 2016 to 2021
$4.6M
(SCANS) Sickle Cell Anemia Neurodevelopmental Screening - Mentoring and Research in Patient Oriented ResearchK24HL148305 · NHLBI · WASHINGTON UNIVERSITY · PI Allison A King · 2019 to 2026
$706k
NHLBI NIH HHS K24 HL148305NHLBI NIH HHS U01 HL133994NHLBI NIH HHS U01 HL133996
6 · The paper itself

Abstract

Silent cerebral infarcts and arteriopathy are common and progressive in individuals with sickle cell anemia. However, most data describing brain lesions in sickle cell anemia are cross-sectional or derive from pediatric cohorts with short follow-up. We investigated the progression of silent cerebral infarct and cerebral vessel stenosis on brain MRI and MRA, respectively, by describing the incidence of new or worsening lesions over a period of up to 25 years among young adults with sickle cell anemia and explored risk factors for progression. Forty-four adults with sickle cell anemia (HbSS or HbSβ

Indexed as

AdolescentAdultAnemia, Sickle CellAntisickling AgentsBlood Transfusion, AutologousBrainCentral Nervous System DiseasesCerebral InfarctionDisease ProgressionErythrocyte TransfusionFemaleHumansHydroxyureaMagnetic Resonance AngiographyMaleRisk FactorsAntisickling AgentsHydroxyureadisease-modifying therapysickle cell anemiasilent cerebral infarctStrokevasculopathyyoung adult

Identifiers

PMID34407676
PMCPMC8649936
OpenAlexW3195548285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.