Evidence map›Paper›PMID 34407651›Full record

ArticleCephalalgia : an international journal of headache2022

Incidence of headache after COVID-19 vaccination in patients with history of headache: A cross-sectional study.

Koji Sekiguchi, Narumi Watanabe, Naoki Miyazaki, Kei Ishizuchi, Chisato Iba, Yu Tagashira, Shunsuke Uno, Mamoru Shibata, Naoki Hasegawa, Ryo Takemura and 2 more

Abstract read
In one paragraph

Article in Cephalalgia : an international journal of headache, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  7. Article
  8. Health equity, care access and quality in headache - part 1.The journal of headache and pain · 2024
    Review
  9. Observational
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. COVID-19 vaccination-triggered cluster headache episodes with frequent attacks.Cephalalgia : an international journal of headache · 2022
    Article
  16. Review
  17. Article
  18. Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2022
    Article
  19. Aseptic meningitis after BNT-162b2 COVID-19 vaccination.Brain, behavior, & immunity - health · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Koji SekiguchiDepartment of Neurology, Keio University School of Medicine, Tokyo, Japan.
Narumi WatanabeDepartment of Neurology, Keio University School of Medicine, Tokyo, Japan.
Naoki MiyazakiBiostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo, Japan.
Kei IshizuchiDepartment of Neurology, Keio University School of Medicine, Tokyo, Japan.
Chisato IbaDepartment of Neurology, Keio University School of Medicine, Tokyo, Japan.
Yu TagashiraDepartment of Neurology, Keio University School of Medicine, Tokyo, Japan.
Shunsuke UnoDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Mamoru ShibataDepartment of Neurology, Keio University School of Medicine, Tokyo, Japan.ORCID 0000-0002-2416-4259
Naoki HasegawaDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Ryo TakemuraBiostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo, Japan.ORCID 0000-0002-3733-7411
Jin NakaharaDepartment of Neurology, Keio University School of Medicine, Tokyo, Japan.
Tsubasa TakizawaDepartment of Neurology, Keio University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHeadache is an adverse event of coronavirus 2019 (COVID-19) vaccination. Whether patients with history of headache suffer more from vaccination-induced headaches is unknown. We aimed to uncover if headache patients develop more headaches after COVID-19 mRNA vaccination than healthy controls.

methodsWe performed a questionnaire survey for nursing staff in our hospital from April to May 2021. Based on baseline characteristics, we divided the participants into migraine, non-migrainous headache, and healthy control, and examined the occurrence and features of headache after COVID-19 vaccinations.

resultsWe included 171 participants (15.2% migraine and 24.6% non-migrainous headache). Headache incidence after vaccinations was significantly higher in the migraine (69.2%) and non-migrainous headache (71.4%) groups than in the healthy control (37.9%) group. The incidence of headaches was significantly higher after the second dose compared to the first (45.6% vs. 20.5%).

conclusionMigraineurs and non-migrainous headache participants developed more headaches compared to the healthy controls after COVID-19 vaccination.

Indexed as

COVID-19COVID-19 VaccinesCross-Sectional StudiesHeadacheHumansIncidenceVaccinationCOVID-19 VaccinesCOVID-19migrainevaccination

Identifiers

PMID34407651
PMCPMC8988452

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.