Evidence map›Paper›PMID 34407624›Full record

ArticleThe American journal of psychiatry2021

Auditory Oddball Responses Across the Schizophrenia-Bipolar Spectrum and Their Relationship to Cognitive and Clinical Features.

David A Parker, Rebekah L Trotti, Jennifer E McDowell, Sarah K Keedy, S Kristian Hill, Elliot S Gershon, Elena I Ivleva, Godfrey D Pearlson, Matcheri S Keshavan, Carol A Tamminga and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

David A ParkerDepartments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Parker, Trotti, McDowell, Clementz); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago (Hill); Department of Psychiatry, UT Southwestern Medical Center, Dallas (Ivleva, Tamminga); Departments of Psychiatry and Neuroscience, Yale School of Medicine, New Haven, Conn. (Pearlson); Olin Center, Institute of Living, Hartford Healthcare Corporation, Hartford, Conn. (Pearlson); and Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Cambridge, Mass. (Keshavan).
Rebekah L TrottiDepartments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Parker, Trotti, McDowell, Clementz); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago (Hill); Department of Psychiatry, UT Southwestern Medical Center, Dallas (Ivleva, Tamminga); Departments of Psychiatry and Neuroscience, Yale School of Medicine, New Haven, Conn. (Pearlson); Olin Center, Institute of Living, Hartford Healthcare Corporation, Hartford, Conn. (Pearlson); and Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Cambridge, Mass. (Keshavan).
Jennifer E McDowellDepartments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Parker, Trotti, McDowell, Clementz); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago (Hill); Department of Psychiatry, UT Southwestern Medical Center, Dallas (Ivleva, Tamminga); Departments of Psychiatry and Neuroscience, Yale School of Medicine, New Haven, Conn. (Pearlson); Olin Center, Institute of Living, Hartford Healthcare Corporation, Hartford, Conn. (Pearlson); and Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Cambridge, Mass. (Keshavan).
Sarah K KeedyDepartments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Parker, Trotti, McDowell, Clementz); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago (Hill); Department of Psychiatry, UT Southwestern Medical Center, Dallas (Ivleva, Tamminga); Departments of Psychiatry and Neuroscience, Yale School of Medicine, New Haven, Conn. (Pearlson); Olin Center, Institute of Living, Hartford Healthcare Corporation, Hartford, Conn. (Pearlson); and Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Cambridge, Mass. (Keshavan).
S Kristian HillDepartments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Parker, Trotti, McDowell, Clementz); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago (Hill); Department of Psychiatry, UT Southwestern Medical Center, Dallas (Ivleva, Tamminga); Departments of Psychiatry and Neuroscience, Yale School of Medicine, New Haven, Conn. (Pearlson); Olin Center, Institute of Living, Hartford Healthcare Corporation, Hartford, Conn. (Pearlson); and Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Cambridge, Mass. (Keshavan).
Elliot S GershonDepartments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Parker, Trotti, McDowell, Clementz); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago (Hill); Department of Psychiatry, UT Southwestern Medical Center, Dallas (Ivleva, Tamminga); Departments of Psychiatry and Neuroscience, Yale School of Medicine, New Haven, Conn. (Pearlson); Olin Center, Institute of Living, Hartford Healthcare Corporation, Hartford, Conn. (Pearlson); and Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Cambridge, Mass. (Keshavan).
Elena I IvlevaDepartments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Parker, Trotti, McDowell, Clementz); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago (Hill); Department of Psychiatry, UT Southwestern Medical Center, Dallas (Ivleva, Tamminga); Departments of Psychiatry and Neuroscience, Yale School of Medicine, New Haven, Conn. (Pearlson); Olin Center, Institute of Living, Hartford Healthcare Corporation, Hartford, Conn. (Pearlson); and Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Cambridge, Mass. (Keshavan).
Godfrey D PearlsonDepartments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Parker, Trotti, McDowell, Clementz); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago (Hill); Department of Psychiatry, UT Southwestern Medical Center, Dallas (Ivleva, Tamminga); Departments of Psychiatry and Neuroscience, Yale School of Medicine, New Haven, Conn. (Pearlson); Olin Center, Institute of Living, Hartford Healthcare Corporation, Hartford, Conn. (Pearlson); and Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Cambridge, Mass. (Keshavan).
Matcheri S KeshavanDepartments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Parker, Trotti, McDowell, Clementz); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago (Hill); Department of Psychiatry, UT Southwestern Medical Center, Dallas (Ivleva, Tamminga); Departments of Psychiatry and Neuroscience, Yale School of Medicine, New Haven, Conn. (Pearlson); Olin Center, Institute of Living, Hartford Healthcare Corporation, Hartford, Conn. (Pearlson); and Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Cambridge, Mass. (Keshavan).
Carol A TammingaDepartments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Parker, Trotti, McDowell, Clementz); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago (Hill); Department of Psychiatry, UT Southwestern Medical Center, Dallas (Ivleva, Tamminga); Departments of Psychiatry and Neuroscience, Yale School of Medicine, New Haven, Conn. (Pearlson); Olin Center, Institute of Living, Hartford Healthcare Corporation, Hartford, Conn. (Pearlson); and Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Cambridge, Mass. (Keshavan).
Brett A ClementzDepartments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens (Parker, Trotti, McDowell, Clementz); Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago (Keedy, Gershon); Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago (Hill); Department of Psychiatry, UT Southwestern Medical Center, Dallas (Ivleva, Tamminga); Departments of Psychiatry and Neuroscience, Yale School of Medicine, New Haven, Conn. (Pearlson); Olin Center, Institute of Living, Hartford Healthcare Corporation, Hartford, Conn. (Pearlson); and Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Cambridge, Mass. (Keshavan).

Funding

Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077851 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TAMMINGA, CAROL A · 2007 to 2019
$7.8M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077945 · NIMH · YALE UNIVERSITY · PI PEARLSON, GODFREY D · 2007 to 2019
$7.6M
Stability of Biotypes: a Longitudinal EvaluationR01MH078113 · NIMH · WAYNE STATE UNIVERSITY · PI KESHAVAN, MATCHERI S. · 2007 to 2019
$6.2M
Stability of Biotypes: a Longitudinal Evaluation (STABLE)R01MH103368 · NIMH · UNIVERSITY OF CHICAGO · PI GERSHON, ELLIOT S, KEEDY, SARAH K · 2015 to 2019
$4.5M
5/5 BIPOLAR-SCHIZOPHRENIA NETWORK FOR INTERMEDIATE PHENOTYPES (B-SNIP) - Resubmission - 1R01MH103366 · NIMH · UNIVERSITY OF GEORGIA · PI CLEMENTZ, BRETT A, GIBBONS, ROBERT D · 2015 to 2019
$3.8M
Bipolar & Schizophrenia Consortium for Parsing Intermediate PhenotypesR01MH077862 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI SWEENEY, JOHN A · 2007 to 2010
$3.1M
3/4-Psychosis & Affective Research Domains and Intermediate Phenotypes (PARDIP)R01MH096957 · NIMH · YALE UNIVERSITY · PI PEARLSON, GODFREY D · 2013 to 2015
$983k
Psychosis and Affective Research Domains and Intermediate Phenotypes (PARDIP)R01MH096913 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TAMMINGA, CAROL A · 2013 to 2015
$950k
4/6 Psychosis and Affective Research Domains and Intermediate Phenotypes (PARDIP)R01MH096942 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KESHAVAN, MATCHERI S. · 2013 to 2015
$783k
4/4-Psychosis and Affective Research Domains and Intermediate Phenotypes (PARDIP)R01MH096900 · NIMH · UNIVERSITY OF GEORGIA · PI CLEMENTZ, BRETT A · 2013 to 2015
$223k
NIMH NIH HHS R01 MH077851NIMH NIH HHS R01 MH077862NIMH NIH HHS R01 MH077945NIMH NIH HHS R01 MH078113NIMH NIH HHS R01 MH096900NIMH NIH HHS R01 MH096913NIMH NIH HHS R01 MH096942NIMH NIH HHS R01 MH096957NIMH NIH HHS R01 MH103366NIMH NIH HHS R01 MH103368
6 · The paper itself

Abstract

objectiveNeural activations during auditory oddball tasks may be endophenotypes for psychosis and bipolar disorder. The authors investigated oddball neural deviations that discriminate multiple diagnostic groups across the schizophrenia-bipolar spectrum (schizophrenia, schizoaffective disorder, psychotic bipolar disorder, and nonpsychotic bipolar disorder) and clarified their relationship to clinical and cognitive features.

methodsAuditory oddball responses to standard and target tones from 64 sensor EEG recordings were compared across patients with psychosis (total N=597; schizophrenia, N=225; schizoaffective disorder, N=201; bipolar disorder with psychosis, N=171), patients with bipolar disorder without psychosis (N=66), and healthy comparison subjects (N=415) from the second iteration of the Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP2) study. EEG activity was analyzed in voltage and in the time-frequency domain (low, beta, and gamma bands). Event-related potentials (ERPs) were compared with those from an independent sample collected during the first iteration of B-SNIP (B-SNIP1; healthy subjects, N=211; psychosis group, N=526) to establish the repeatability of complex oddball ERPs across multiple psychosis syndromes (r values >0.94 between B-SNIP1 and B-SNIP2).

resultsTwenty-six EEG features differentiated the groups; they were used in discriminant and correlational analyses. EEG variables from the N100, P300, and low-frequency ranges separated the groups along a diagnostic continuum from healthy to bipolar disorder with psychosis/bipolar disorder without psychosis to schizoaffective disorder/schizophrenia and were strongly related to general cognitive function (r=0.91). P50 responses to standard trials and early beta/gamma frequency responses separated the bipolar disorder without psychosis group from the bipolar disorder with psychosis group. P200, N200, and late beta/gamma frequency responses separated the two bipolar disorder groups from the other groups.

conclusionsNeural deviations during auditory processing are related to psychosis history and bipolar disorder. There is a powerful transdiagnostic relationship between severity of these neural deviations and general cognitive performance. These results have implications for understanding the neurobiology of clinical syndromes across the schizophrenia-bipolar spectrum that may have an impact on future biomarker research.

Indexed as

Bipolar DisorderPsychotic DisordersAcoustic StimulationAdultAuditory PathwaysCognitionCorrelation of DataDiagnosis, DifferentialElectroencephalographyEvoked Potentials, AuditoryFemaleHumansMaleNeural PathwaysPsychological TechniquesSeverity of Illness IndexBiological MarkersBipolar and Related DisordersEEGP300Schizophrenia Spectrum and Other Psychotic Disorders

Identifiers

PMID34407624
PMCPMC12082645

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.