Evidence map›Paper›PMID 34407416›Full record

ArticleCell reports2021

Mds1

Yi Zhang, Kathleen E McGrath, Edward Ayoub, Paul D Kingsley, Hongbo Yu, Kate Fegan, Kelly A McGlynn, Sarah Rudzinskas, James Palis, Archibald S Perkins

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Spatiotemporal dynamics of fetal liver hematopoietic niches.The Journal of experimental medicine · 2025
    Article
  8. Review
  9. Article
  10. Fate-Mapping Macrophages: From Ontogeny to Functions.Methods in molecular biology (Clifton, N.J.) · 2024
    Review
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yi ZhangDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Kathleen E McGrathCenter for Pediatric Biomedical Research and Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA.
Edward AyoubDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA; Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Paul D KingsleyCenter for Pediatric Biomedical Research and Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA.
Hongbo YuDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
Kate FeganCenter for Pediatric Biomedical Research and Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA.
Kelly A McGlynnDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA; Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Sarah RudzinskasDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.
James PalisCenter for Pediatric Biomedical Research and Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA.
Archibald S PerkinsDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA. Electronic address: archibald_perkins@urmc.rochester.edu.
University of Rochester Medical Center · US

Funding

Macrophage regulation of the erythronR01DK119285 · NIDDK · UNIVERSITY OF ROCHESTER · PI ELLIOTT, MICHAEL RUSTY, PALIS, JAMES · 2019 to 2023
$2.3M
Function of the PR domain of the MDSI-EVI1 in MLL fusion protein leukemogenesisR01CA175761 · NCI · UNIVERSITY OF ROCHESTER · PI PERKINS, ARCHIBALD S. · 2014 to 2018
$1.6M
Mechanism of EVI1-induced LeukemogenesisR01CA120313 · NCI · UNIVERSITY OF ROCHESTER · PI PERKINS, ARCHIBALD S. · 2007 to 2011
$1.6M
NCI NIH HHS R01 CA120313NCI NIH HHS R01 CA175761NIDDK NIH HHS R01 DK119285
6 · The paper itself

Abstract

Hematopoietic ontogeny consists of two broad programs: an initial hematopoietic stem cell (HSC)-independent program followed by HSC-dependent hematopoiesis that sequentially seed the fetal liver and generate blood cells. However, the transition from HSC-independent to HSC-derived hematopoiesis remains poorly characterized. To help resolve this question, we developed Mds1

Indexed as

AllelesAgingAnimalsCell LineageEmbryo, MammalianFetusHemangioblastsHematopoiesisHematopoietic Stem CellsIntegrasesLiverMDS1 and EVI1 Complex Locus ProteinMiceMice, Inbred C57BLMice, TransgenicTamoxifenCre recombinaseIntegrasesMDS1 and EVI1 Complex Locus ProteinTamoxifenCre recombinaseembryonic hematopoiesisfetal hematopoietic stem cellsfetal liverhematopoietic ontogenylineage tracingmacrophage developmentmouse model

Identifiers

PMID34407416
PMCPMC8428393
OpenAlexW3193311352

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.