Evidence map›Paper›PMID 34407334›Full record

ArticleThe New England journal of medicine2021

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19.

Morris J Brown, William Alazawi, Stavroula Kanoni

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in The New England journal of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
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  6. Review
  7. Rare Disease Drug Repurposing.JAMA network open · 2025
    Article
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  10. Article
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  15. COVID-19 and Multiorgan Response: The Long-Term Impact.Current problems in cardiology · 2023
    Review
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  17. Review
  18. Article
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  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Morris J BrownQueen Mary University of London, London, United Kingdom morris.brown@qmul.ac.uk.
William AlazawiQueen Mary University of London, London, United Kingdom morris.brown@qmul.ac.uk.
Stavroula KanoniQueen Mary University of London, London, United Kingdom morris.brown@qmul.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19Critical IllnessHumansReceptors, Interleukin-6SARS-CoV-2Receptors, Interleukin-6

Identifiers

PMID34407334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.