ArticleHuman brain mapping2021
White matter degeneration revealed by fiber-specific analysis relates to recovery of hand function after stroke.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Fixel-Based White Matter Correlates of Sentence Comprehension in Post-Stroke Aphasia.Brain sciences · 2025Article
- Experimental Ischemic Stroke Induces Secondary Bihemispheric White Matter Degeneration and Long-Term Cognitive Impairment.Translational stroke research · 2025Article
- Longitudinal microstructural alterations surrounding subcortical ischemic stroke lesions detected by free-water imaging.Human brain mapping · 2024Article
- Intracortical and intercortical networks in patients after stroke: a concurrent TMS-EEG study.Journal of neuroengineering and rehabilitation · 2023Article
- Mapping correlated neurological deficits after stroke to distributed brain networks.Brain structure & function · 2022Review
- White matter degeneration revealed by fiber-specific analysis relates to recovery of hand function after stroke.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent developments of higher-order diffusion-weighted imaging models have enabled the estimation of specific white matter fiber populations within a voxel, addressing limitations of traditional imaging markers of white matter integrity. We applied fixel based analysis (FBA) to investigate the evolution of fiber-specific white matter changes in a prospective study of stroke patients and upper limb motor deficit over 1 year after stroke. We studied differences in fiber density and macrostructural changes in fiber cross-section. Motor function was assessed by grip strength. We conducted a whole-brain analysis of fixel metrics and predefined corticospinal tract (CST) region of interest in relation to changes in motor functions. In 30 stroke patients (mean age 62.3 years, SD ±16.9; median NIHSS 4, IQR 2-5), whole-brain FBA revealed progressing loss of fiber density and cross-section in the ipsilesional corticospinal tract and long-range fiber tracts such as the superior longitudinal fascicle and trans-callosal tracts extending towards contralesional white matter tracts. Lower FBA metrics measured at the brainstem section of the CST 1 month after stroke were significantly associated with lower grip strength 3 months (p = .009, adjusted R
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.